⁶⁸Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas - Imaging analysis and histological validation.

ABSTRACT:

Background

Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using ⁶⁸Ga-labelled FAP-Inhibitors (⁶⁸Ga-FAPI-PET/CT) and their clinical potential for staging and radiotherapy planning in 12 ACC patients (7 primary, 5 recurrent).

Patients and methods

Patients underwent contrast enhanced staging CT (ceCT) and magnetic resonance imaging (ceMRI) before ⁶⁸Ga-FAPI - PET/CT. PET-scans were acquired 10, 60 and

SUBMITTER: Rohrich M 

PROVIDER: S-EPMC9913884 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature