Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.

ABSTRACT:

Background

People with cocaine use disorder (CUD) often have abnormal cognitive function and brain structure. Cognition is supported by brain networks that typically have characteristics like rich-club organization, which is a group of regions that are highly connected across the brain and to each other, and small worldness, which is a balance between local and long-distance connections. However, it is unknown whether there are abnormalities in structural brain network connectivity of CUD.

Methods

Using diffusion-weighted imaging, we measured structural connectivity in 37 people with CUD and 38 age-matched controls. We identified differences in rich-club organization and whether such differences related to small worldness and behavior. We also tested whether rich-club reorga

SUBMITTER: Hall SA 

PROVIDER: S-EPMC9948276 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature