Low HDL-c levels at admission are associated with greater severity and worse clinical outcomes in patients with COVID-19 disease.

ABSTRACT:

Background and aims

HDL particles may act to buffer host cells from excessive inflammatory mediators. The aim of this study is to investigate if the lipid profile provides a prognostic biomarker for COVID-19 outcomes.

Methods

This was a prospective study of the characteristics of 125 adult COVID-19 patients with a lipid profile performed on the day of admission analyzed with regard to clinical outcomes.

Results

Seventy-seven patients (61.2%) were men, with a mean age of 66.3 (15.6) years. 54.1% had bilateral pneumonia. The all-cause mortality rate during hospitalization was 20.8%. We found a direct association between more severe disease assessed by the WHO classification, admission to the ICU and death with more pronounced lymphopenia, higher levels of CRP, ferritin

SUBMITTER: Parra S 

PROVIDER: S-EPMC9988188 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature