Dataset Information
Andersen2017 - Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development
Ontology highlight
ABSTRACT: This is a mathematical model investigating the role of chronic inflammation in the development and progression of myeloproliferative neoplasms (MPNs). The model describes the proliferation from stem cells to mature cells, including mutations of healthy stem cells to become malignant stem cells. The model also features a simple inflammatory coupling coping with cell death and affecting the basic model beneath.
SUBMITTER: Lucian Smith
PROVIDER: MODEL1911120005 | biostudies-other |
SECONDARY ACCESSION(S): 28859112
REPOSITORIES: biostudies-other
Publications
Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development.
PloS one 20170831 8
The chronic Philadelphia-negative myeloproliferative neoplasms (MPNs) are acquired stem cell neoplasms which ultimately may transform to acute myelogenous leukemia. Most recently, chronic inflammation has been described as an important factor for the development and progression of MPNs in the biological continuum from early cancer stage to the advanced myelofibrosis stage, the MPNs being described as "A Human Inflammation Model for Cancer Development". This novel concept has been built upon clin ...[more]
