Unknown

Dataset Information

0

Opposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value

ABSTRACT: Analysis of reciprocal modulation of Runx2 and E2 signaling in BCA. Our objective was to investigate whether the interaction between estrogen and Runx2 signaling in breast cancer (BCa) could help refine an estrogen-responsive gene signature with improved prognostic value. MCF7/Rx2dox BCa cells conditionally expressing Runx2 upon doxycycline treatment were treated with estradiol and/or doxycycline to induce Runx2, and global gene expression was profiled to define genes regulated by estradiol, Runx2, or both.

ORGANISM(S): Homo sapiens

SUBMITTER: Chimge NO 

PROVIDER: S-ECPF-GEOD-30597 | biostudies-other | 2012 Feb

REPOSITORIES: biostudies-other

Json Xml

Similar Datasets

Transcriptomics Opposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value.
2012-03-06 | E-GEOD-30597 | biostudies-arrayexpress
Transcriptomics Opposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value.
2012-03-06 | GSE30597 | GEO
Unknown Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness.
| S-EPMC3277803 | biostudies-literature
Unknown Identification of a Six-lncRNA Signature With Prognostic Value for Breast Cancer Patients.
| S-EPMC7396575 | biostudies-literature
Unknown Identification of methylation sites and signature genes with prognostic value for luminal breast cancer.
| S-EPMC5896050 | biostudies-literature
Unknown Identification of a six-gene signature with prognostic value for patients with endometrial carcinoma.
| S-EPMC6247034 | biostudies-literature
Unknown Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients.
| S-EPMC8165796 | biostudies-literature
Unknown Identification and prognostic value of a glycolysis-related gene signature in patients with bladder cancer.
| S-EPMC7837905 | biostudies-literature
Unknown Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types.
| S-EPMC2600688 | biostudies-literature
Unknown Comprehensive Analysis and Identification of an Immune-Related Gene Signature with Prognostic Value for Prostate Cancer.
| S-EPMC8254424 | biostudies-literature