Genomics

Dataset Information

55

Whole-genome analysis of heat shock factor binding sites in Drosophila melanogaster at room temperature


ABSTRACT: Whole-genome analysis of heat shock factor binding sites in Drosophila melanogaster. Heat shock factor IP DNA from non-shock (room temperature) Kc 167 cells compared to whole cell extract on Agilent 2x244k tiling arrays. Overall design: Heat Shock Factor IP vs whole cell extract from non-shock (room temperature) Kc cells.

INSTRUMENT(S): Agilent 1 million-probe custom array from UHN/CDMC

SUBMITTER: Zak Razak  

PROVIDER: GSE22335 | GEO | 2011-01-05

SECONDARY ACCESSION(S): PRJNA127509

REPOSITORIES: GEO

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Publications

Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster.

Gonsalves Sarah E SE   Moses Alan M AM   Razak Zak Z   Robert Francois F   Westwood J Timothy JT  

PloS one 20110114 1


During heat shock (HS) and other stresses, HS gene transcription in eukaryotes is up-regulated by the transcription factor heat shock factor (HSF). While the identities of the major HS genes have been known for more than 30 years, it has been suspected that HSF binds to numerous other genes and potentially regulates their transcription. In this study, we have used a chromatin immunoprecipitation and microarray (ChIP-chip) approach to identify 434 regions in the Drosophila genome that are bound b  ...[more]

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