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Mineralized collagen induces phenotypic changes in MDA-MB-231

ABSTRACT: We examine the transcriptional alterations induced by in vitro culture of MDA-MB-231 cells on microfabricated hydroxyapatite-mineralized collagen devices that simulate bone matrix (PMID 29759731). As a control, we additionally characterize the transcriptional activity of cells cultured on a collagen substrate. We find that mineralized collagen increases the expression of genes associated with stemness and metastasis while culture on collagen increased expression of genes associated with cell cycle progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229094 | GEO | 2023/07/19

REPOSITORIES: GEO

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