Transcriptomics

Dataset Information

18

IL-6-mediated activation of STAT3α prevents trauma/hemorrhagic shock-induced liver inflammation


ABSTRACT: We previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of resuscitation, however the mechanism(s) for the IL-6 protective effect is not fully known. We used microarrays to detail the global gene expression in response to T/HS and the effect of IL-6 on this model with and without pharmacologic blockade of Stat3-mediated IL-6 and identified distinct members of the inflammasome de-regulated during T/HS that normalized with IL-6 administration during resuscitation. Overall design: Adult male rats were subjected to either sham procedure, a trauma plus hemorrhagic shock (T/HS) procedure, T/HS with IL-6 versus PBS during resuscitation, or pretreatment with pharmacologic blockade of Stat3-mediated IL6 via GQ-ODN and after procedural completion, animals were sacrificed and livers were taken and homegenized for RNA extraction and microarray analysis using Affymetrix Rat 230A GeneChip® array

INSTRUMENT(S): [RAE230A] Affymetrix Rat Expression 230A Array

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Stephen Andrew Thacker  

PROVIDER: GSE27978 | GEO | 2011-03-16

SECONDARY ACCESSION(S): PRJNA137777

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2014-06-02 | E-GEOD-27978 | ArrayExpress
2012-12-17 | E-GEOD-26696 | ArrayExpress
2011-11-27 | E-GEOD-26695 | ArrayExpress
2011-01-24 | GSE26696 | GEO
2007-07-25 | GSE6332 | GEO
2012-03-27 | E-GEOD-6332 | ArrayExpress
| GSE89406 | GEO
| GSE55674 | GEO
| GSE84178 | GEO
2014-06-02 | E-GEOD-43800 | ArrayExpress