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Effect of glutamine deprivation on naïve CD4+ T cells differentiation

ABSTRACT: Glutamine availability is a major determinant of T-cell metabolism and function. To define the transcriptional consequences of glutamine deprivation during human T-cell activation, we performed bulk RNA sequencing of naïve CD4+ T cells stimulated through the T-cell receptor under glutamine-free or physiological-range glutamine conditions. This dataset enables analysis of glutamine-dependent transcriptional programs in activated CD4+ T cells, including pathways related to cellular stress, redox regulation and inflammatory signalling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE344322 | GEO | 2026/08/23

REPOSITORIES: GEO

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