Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Metabolic Syndrome Plasma Lipidomics

ABSTRACT: Plasma of metabolic syndrome patients will be checked for lipidomic profiles

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

DISEASE(S): Metabolic Syndrome

SUBMITTER: Maureen Kachman

PROVIDER: ST000663 | MetabolomicsWorkbench | Mon Jun 05 00:00:00 BST 2017

REPOSITORIES: MetabolomicsWorkbench

ACCESS DATA

Json Xml

Similar Datasets

Metabolomics Workbench ST000663 - GNPS - Metabolic Syndrome Plasma Lipidomics

Project description:Plasma of metabolic syndrome patients will be checked for lipidomic profiles

2018-08-02 | MSV000082716 | GNPS

MicroRNAs in plasma in metabolic syndrome.

Project description:Comparison between miRNA expression in plasma of women with and without metabolic syndrome. We used microarrays to compare the composition of miRNAs in plasma of participants with and without metabolic syndrome (ATP III criteria).

2023-10-02 | GSE239866 | GEO

Circulating MicroRNAs as Biomarkers of Metabolic Syndrome

Project description:Metabolic syndrome is a common and complicated metabolic disorder and defined as a clustering of metabolic risk factors such as insulin resistance or diabetes, obesity, hypertension, and hyperlipidemia. The identification of accurate and effective biomarkers is beneficial to the early diagnosis and treatment of metabolic syndrome. Our study firstly detected the plasma miRNA expression profile of MetS patients compared with control group by high-throughput sequencing and integrated bioinformatics approaches. To our best knowledge, our study firstly perform high-throughput sequencing to obtain the circulating microRNA expression data in MetS plasma, and identified several potential plasma biomarkers for MetS.

2023-07-24 | GSE155096 | GEO

Identification of A Blood-based 9-hub-gene Signature for Metabolic Syndrome by Machine Learning Algorithms and Integrated Bioinformatics Analysis

Project description:In this work, plasma samples of 5 metabolic syndrome patients and 5 healthy volunteers were collected. Then, high-throughput RNA sequencing was performed to detect the expression of plasma coding RNA.

2021-05-29 | E-MTAB-10494 | biostudies-arrayexpress

Small RNA-Seq of plasma-derived exosomes from Acute Respiratory Distress Syndrome patients and healthy subjects

Project description:Despite a significant progress in the treatment of Acute Respiratory Distress Syndrome (ARDS), our ability to identify early patients and predict outcome remains limited. In this study, we aimed to characterize small RNA content of plasma exosomes from ARDS patients in order to identify potential diagnostic biomarkers of the disease. For the first time, we profiled miRNA expression levels in plasma-derived exosomes from ARDS patients (n=8) compared to healthy subjects (n=10) by small RNA-seq. It allowed us to identify 12 exosomal miRNAs differentially expressed in ARDS context (padj<0.05).

2021-01-19 | E-MTAB-9991 | biostudies-arrayexpress

Pilot Plasma Proteomic Study of Steroid Resistance in Pediatric Nephrotic Syndrome

Project description:Pilot proteomic study of immunodepleted plasma samples comparing steroid sensitive and steroid resistant pediatric nephrotic syndrome patients.

2018-02-27 | MSV000082114 | MassIVE

Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome – A Preliminary Open Study

Project description:Clinical studies have demonstrated that higher protein intake based on caloric restriction (CR) alleviates metabolic abnormalities. However, no study has examined the effects of plasma protein profiles on caloric restriction with protein supplementation (CRPS) in metabolic syndrome (MetS). Therefore, using a proteomic perspective, this pilot study investigated whether CRPS ameliorated metabolic abnormalities associated with MetS in middle-aged women. Methods: Plasma samples of middle-aged women with MetS in CR and CRPS groups for 12-week intervention were obtained and their protein profiles were analysed. Briefly, blood samples from qualified participants were drawn before and after the dietary treatment. Anthropometric, clinical, and biochemical variables were measured and correlated with plasma proteomics. Results: In results, we found that body mass index, total body fat, and fasting blood glucose decreased significantly after the interventions but were not different between the CR and CRPS groups. After liquid chromatography–tandem mass spectrometry analysis, the relative plasma levels of A2M, C4BPA, C1RL, C6, C8G, and PROS were significantly different between the CRPS and CR groups. These proteins are involved in inflammation, the immune system, and coagulation responses. Moreover, blood low-density lipoprotein cholesterol levels were significantly and positively correlated with C6 plasma levels in both groups. Conclusions: These findings suggest that CRPS improves inflammatory responses in middle-aged women with MetS. Specific plasma protein expression (i.e. A2M, C4BPA, C1RL, C6, C8G, and PROS) associated with the complement system was highly correlated with FBG, BLs, and body fat.

2019-11-13 | PXD012213 | Pride

Transcription profiling of human pulmonary epithelial cells cultured in plasma from sickle cell disease acute chest syndrome and steady-state patients

Project description:Clinical variability in sickle cell disease (SCD) suggests a role for extra-erythrocytic factors in the pathogenesis of vasoocclusion. We hypothesized that one potential factor, endothelial dysfunction, results from induction of phenotypic changes by circulating factors in SCD patients. The database reports gene expression in cultured human pulmonary artery endothelial cells (HPAEC) exposed to plasma from: a) sickle acute chest syndrome (ACS) patients (samples ; b) SCD patients at steady-state and c) normal volunteers using microarrays (U133A-B GeneChip Affymetrix).

2007-08-25 | E-GEOD-1849 | biostudies-arrayexpress

Transcriptional changes in blood from metabolic syndrome patients after a period of high intensity interval training

Project description:Abstract The metabolic syndrome is a cluster of conditions that predispose for diabetes and cardiovascular disease. Nine metabolic syndrome patients were recruited to 48 workouts of interval training. At the end of the study, all patients significantly reduced their risk of cardiovascular disease (in terms of VO2max, blood pressure and plasma lipid). Exercise-induced transcriptional changes may provide new mechanistically insights in the area of improved health by exercise. Aim: Determine whether transcriptional changes occurred in the blood cells of patients after the exercise program. We hypothesized that significantly altered biological processes in blood would include a set of genes at least partly responsible for the improvement seen in this patient group after the exercise programme. Methods: Blood from five patients were collected in PAXgene tubes pre and post the exercise period. RNA was extracted and run on microarrays. Results: Gene set enrichment analysis revealed twelve significantly enriched biological processes and molecular functions that were up-regulated post exercise. Seven processes and functions were down-regulated (nom p-value <0.05). Exercise induced a down-regulation of plasma mRNA- and protein levels of arginase-I and vWf, which might explain improved risk profile and endothelial function of the metabolic syndrome patients. Conclusion: After the exercise period was completed, the metabolic syndrome patients had decreased transcription of genes associated with blood clotting and steroid metabolism. Arginase-I was decreased post exercise, which may explain the previous reported improved NO-availability and endothelial function. Keywords: aerobic capacity, cardiovascular disease, microarray, arginase, blood clotting

2008-06-01 | GSE10540 | GEO

AGO2 Plasma exRNA Profiles

Project description:AGO2 Plasma exRNA Profiles

| PRJNA511445 | ENA