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Epithelial-mesenchymal transition and extracellular matrix production

ABSTRACT: This project used a quantitative proteomics approach to study the molecular mechanism in regulating the production of extracellular matrix proteins by mesenchymal cells

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Yingxin Zhao

LAB HEAD: Yingxin Zhao, Ph.D.

PROVIDER: PXD008585 | Pride | 2021-08-30

REPOSITORIES: Pride

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Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation To Maintain Proteostasis and Extracellular Matrix Production.

Zhang Jing J Jamaluddin Mohammad M Zhang Yueqing Y Widen Steven G SG Sun Hong H Brasier Allan R AR Zhao Yingxin Y

Journal of proteome research 20190828 9

Type II epithelial-mesenchymal transition (EMT) plays a vital role in airway injury, repair, and remodeling. Triggered by growth factors, such as transforming growth factor beta (TGFβ), EMT induced a biological process that converts epithelial cells into secretory mesenchymal cells with a substantially increased production of extracellular matrix (ECM) proteins. Epithelial cells are not professional secretory cells and produce few ECM proteins under normal conditions. The molecular mechanism und ...[more]

PMID: 31424945

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