Dataset Information
Thermal proteome profiling of cell cycle
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Andre Mateus
LAB HEAD: Mikhail M. Savitski
PROVIDER: PXD008646 | Pride | 2018-05-02
REPOSITORIES: Pride
Publications
Pervasive Protein Thermal Stability Variation during the Cell Cycle.
Cell 20180426 6
Quantitative mass spectrometry has established proteome-wide regulation of protein abundance and post-translational modifications in various biological processes. Here, we used quantitative mass spectrometry to systematically analyze the thermal stability and solubility of proteins on a proteome-wide scale during the eukaryotic cell cycle. We demonstrate pervasive variation of these biophysical parameters with most changes occurring in mitosis and G1. Various cellular pathways and components var ...[more]
