The cGAS-STING pathway drives type I IFN immunopathology in COVID-19
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Vivek Thacker
LAB HEAD: Andrea Ablasser
PROVIDER: PXD030753 | Pride | 2022-04-04
REPOSITORIES: Pride
Publications
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
Domizio Jeremy Di JD Gulen Muhammet F MF Saidoune Fanny F Thacker Vivek V VV Yatim Ahmad A Sharma Kunal K Nass Théo T Guenova Emmanuella E Schaller Martin M Conrad Curdin C Goepfert Christine C de Leval Laurence L Garnier Christophe von CV Berezowska Sabina S Dubois Anaëlle A Gilliet Michel M Ablasser Andrea A
Nature 20220119 7899
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications<sup>1,2</sup>. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs <sup>3-5</sup>). Although rapid induction of type I IFNs limits virus propagation, a sustained increase in the levels of type I IFNs in the late phase of the infection is associated with aberrant inflammation and poor clinical outcome<sup>5-17</sup>. Here we show that the c ...[more]
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