Dataset Information

Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

ABSTRACT: AKAP11 deficiency is associated with autophagy-regulated PKA and neuronal activity in mouse brains. We hypothesized that the differentially expressed proteins (DEPs) and phospho-proteins (pDEPs) in AKAP11 conditional KO mice and human iPSC-induced neurons (iNs) could be identified as potential AKAP11-PKA targets. We have generated AKAP11 F/F; Syn-Cre KO mice, AKAP11-eGFP;Syn-cre KI mice, AKAP11 KO iNs from human iPSCs using CRISPR/Cas9 and constitutive AKAP11 knockout mice

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Brain, Stem Cell

SUBMITTER: Zhiping Wu

LAB HEAD: Junmin Peng

PROVIDER: PXD067156 | Pride | 2025-12-08

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20240129_091540_11phos_yue_Report.tsv	Tabular
	APP_KI_Batch01_f01.1.pepXML	Pepxml
	APP_KI_Batch01_f01.raw	Raw
	APP_KI_Batch01_f02.1.pepXML	Pepxml
	APP_KI_Batch01_f02.raw	Raw

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Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission.

Lee You-Kyung YK Xiao Cong C Zhou Xiaoting X Wang Le L McReynolds Meghan M Wu Zhiping Z Han Xian X Purisic Eric E Kim Henry H Li Xianting X Pang Zhiping Z Dai Jinye J Peng Junmin J Yang Nan N Yue Zhenyu Z

Nature communications 20251128 1

Human genomic studies have identified protein-truncating variants in AKAP11 associated with both bipolar disorder (BD) and schizophrenia (SCZ), implicating a shared disease mechanism driven by loss-of-function. AKAP11, a protein kinase A (PKA) adapter, plays a key role in degrading the PKA-RI complex through selective autophagy. However, the neuronal functions of AKAP11 and the impact of its loss-of-function remains largely uncharacterized. Through multi-omics approaches, cell biology, and elect ...[more]

PMID: 41315293

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