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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [ATAC-seq]

ABSTRACT: Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [ATAC-seq]

PROVIDER: PRJNA1070555 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27783392_1.fastq.gz	Fastqsanger.gz
	SRR27783392_2.fastq.gz	Fastqsanger.gz
	SRR27783393_1.fastq.gz	Fastqsanger.gz
	SRR27783393_2.fastq.gz	Fastqsanger.gz
	SRR27783394_1.fastq.gz	Fastqsanger.gz

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.

Project description:Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [ATAC-seq]

Project description:We discovered a role for the transcription factor OTX2 in formation of mouse definitive endoderm (DE). We used ATAC-seq to identify open chromatin regions in OTX2-depleted definitive endoderm cells and identify sites with changed accessibility during DE differentiation

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [PS_CUTnRUN]

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm.

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [PS_CUTnRUN]

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [CUTnTAG]

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [scRNA_PS_Meso]

Project description:Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [scRNA_PS_Meso]

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Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [CUT&RUN]

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Project description:We discovered a role for the transcription factor OTX2 in formation of mouse definitive endoderm (DE). We used CUT&TAG to map H3K27ac- and H3K4me1-bound genomic regions and identify OTX2-bound enhancers during directed differentiation of EpiSCs to Primitive Streak (PS) intermediates and DE

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