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Transcriptomic analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns.

ABSTRACT: Transcriptomic analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns.

PROVIDER: PRJNA418172 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6286170.fastq.gz	Fastqsanger.gz
	SRR6286171.fastq.gz	Fastqsanger.gz
	SRR6286172.fastq.gz	Fastqsanger.gz
	SRR6286164.fastq.gz	Fastqsanger.gz
	SRR6286165.fastq.gz	Fastqsanger.gz

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miRNA-Seq analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns

Project description:miRNA-Seq analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns

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Transcriptomic analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns.

Project description:Purpose: To examine differential expression of genes in bovine macrophages under the influence of Toll-like receptor agonists. Goal: to study and understand the early phase of transcriptomic changes induced by Toll-like receptor in bovine macrophage cell line.

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miRNA-Seq analysis of the early phase of BoMac cell stimulation with a viral and a bacterial pathogen associated molecular patterns

Project description:Purpose: To examine differential expression of miRNA in bovine macrophages under the influence of Toll-like receptor agonists. Goal: to study and understand the miRNA regulation of early phase of transcriptomic changes induced by Toll-like receptor in bovine macrophage cell line.

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Effect of M . bovis NX2-EVs on gene expression in BoMac cells

Project description:Our research shows that EVs derived from M. bovis-infected BMEC cells (EVs-M. bovis NX2) could regulate BoMac cell injury by inducing inflammation. To detect the effect of EVs-M. bovis NX2 on gene expression in BoMac cells, we incubated Ctrl-EVs and EVs-M. bovis NX2 with BoMac cells for 12h, 24h. Our data provide globaly change of mRNA profile caused by EVs-M. bovis NX2.

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Effect of MbovP475 on gene expression in BoMac cells

Project description:MbovP475 of M. bovis is a nucleomodulin and has the ability to enter into cells nucleus during infection. Recently, we verifed that MbovP475 can regulate the hostone PTMs. To detect the effect of MbovP475 of M. bovis on gene expression in BoMac cells, we constructed BoMac cells stablely expressing MbovP475. Our data provide globaly change of mRNA profile caused by MbovP475.

2026-06-03 | GSE278667 | GEO

Effect of MbovP475 on gene expression in BoMac cells [ChIP-seq]

Project description:MbovP475 of M. bovis is a nucleomodulin and has the ability to enter into cells nucleus during infection. Recently, we verifed that MbovP475 can regulate the hostone PTMs. We found MbovP475 promoted the H3K4me3 and H3K27ac. So we proposed MbovP475 regulated gene expression in BoMac cells by promoting H3K4me3 and H3K27a, we constructed BoMac cells stablely expressing MbovP475. Our data provide globaly genes marked by H3K4me3 and H3K27ac enhanced by MbovP475.

2026-06-03 | GSE278712 | GEO

Mycoplasma bovis nucleomodulin MbovP202 modulates gene expression in BoMac cells

Project description:We identified a novel M. bovis nucleomodulin, MbovP202, which functions as a 5-methylcytosine-specific DNA methyltransferase that localizes to the nucleus of the bovine macrophage cell line (BoMac). To investigate its regulatory role, we performed RNA sequencing to compare the mRNA expression profiles between BoMac and BoMacMbovP202 cells. A total of 2,790 differentially expressed genes (DEGs) were identified between the two groups. Integrated analysis of Whole Genome Bisulfite Sequencing (WGBS) and RNA-Seq data revealed that genes with promoter hypermethylation and concomitant down-regulated expression were predominantly enriched in metabolic and inflammatory pathways.

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Genome-wide maps of MbovP475-binding sits in BoMac cells.

Project description:We used Next-generation sequencing (NGS) to reveal MbovP475-binding sites in BoMac cells. We extracted the genome of BoMac infected with mycoplasma bovis by sonication, then the sheared chromatin in the supernatant was incubated with purified rabbit polyclonal IgG against MbovP475 and protein A/G magnetic beads. The DNA was eluted from the beads and subject to making sequencing library. We totally got 2648 potential MbovP475-binding sites by ChIP-seq. Among them, CRYAB and MCF2L2 gene were further verifed to be down-reguated by MbovP475 through binding to the promoter region of two genes.

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Mycoplasma bovis nucleomodulin MbovP202 modulates DNA methylation in BoMac cells

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The AT-hook DNA binding protein, TashAT2 of Theileria annulata acts as an analogue of mammalian HMGA to tune the BoMac cell transcriptome

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2023-05-22 | E-MTAB-9680 | biostudies-arrayexpress

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