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ProteomicsFine-tuning regulation of (p)ppGpp-driven outer membrane vesicle formation in Acinetobacter baumannii
While the roles of (p)ppGpp on cytosolic proteins are well established, its effects on membrane remodeling remain elusive. The translocation of signal recognition particle (SRP)-dependent proteins can be regulated by binding (p)ppGpp to two key GTPase components: FtsY, which interacts with SecYEG, a...
ORGANISM(S): Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 
2025-03-15 | PXD057710 | Pride
Membrane remodeling Membrane disruption Acinetobacter baumannii Outer membrane vesicle Stringent response (p)ppgpp 
Proteomics(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains
Escherichia coli RelA is a ribosomal factor with strong (p)ppGpp synthesis activity that is dramatically activated in the presence of deacylated tRNA in the ribosomal A-site. RelA is a unique enzyme in that it is directly positively regulated by its product, alarmone nucleotide (p)ppGpp. Using HDX-M...
ORGANISM(S): Escherichia coli 
2021-08-11 | PXD019953 | Pride
Escherichia coli / stringent response / rela / (p)ppgpp 
ProteomicsThe alarmone (p)ppGpp is part of the heat shock response of Bacillus subtilis
Here, B. subtilis was used as a model organism to investigate how cells respond and adapt to proteotoxic stress conditions. Our experiments suggested that the stringent response, caused by raised levels of the (p)ppGpp alarmone, plays a role during thermotolerance development and the heat shock resp...
ORGANISM(S): Bacillus subtilis GB03 
2020-03-09 | PXD015416 | Pride
Bacillus subtilis  heat stress response  stringent response  (p)ppgpp  alarmone  rel  spx 
GenomicsFunctional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii
Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii
PRJNA1290938 | ENA
ProteomicsE.coli (p) ppGpp regulation.E. coli, ppGpp, growth rate
These two projects are about the proteome of wild type E. coli K-12 NCM3722 strain (RE198LQ) and its rpoS-null strain (XA00994LQ). Both projects include replicates of two conditions, the normal conditions and (p)ppGpp overproduction conditions via RelA* OE.
ORGANISM(S): Escherichia coli O104:H4 str. 01-09591 
2023-12-20 | PXD042250 | Pride
Growth rate E. coli Ppgpp 
ProteomicsVibrio cholerae (p)ppGpp and DksA mutants SWATH
This study elucidates the whole proteome changes in the wild type and gnetically modified strains of Vibrio cholerae. Label-free SWATH-MS is used for protein quantitation following genetic modifications in alarmone (p)ppGpp metabolizing genes and transcription factor DksA.
ORGANISM(S): Vibrio cholerae O1 str. Haiti 
2025-01-29 | PXD055059 | Pride
Lc-msms Vibrio cholerae Dksa Swath-ms (p)ppgpp 
GenomicsTranscriptional regulation by the stringent response-associated alarmone (p)ppGpp in Pseudomonas putida
Transcriptional regulation by the stringent response-associated alarmone (p)ppGpp in Pseudomonas putida
PRJNA1185757 | ENA
GenomicsThe role of (p)ppGpp in the heat shock response in B. subtilis
The role of (p)ppGpp in the heat shock response in B. subtilis
PRJNA516445 | ENA
Genomics(p)ppGpp-dependent activation of gene expression during nutrient limitation
(p)ppGpp-dependent activation of gene expression during nutrient limitation
PRJNA1293426 | ENA
Genomics(p)ppGpp promotes Enterococcus faecalis virulence in a murine model of catheter-associated urinary tract infection
(p)ppGpp promotes Enterococcus faecalis virulence in a murine model of catheter-associated urinary tract infection
PRJNA544676 | ENA
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