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MetabolomicsDisturbed Microbiota-Metabolites-Immune Interaction Network is Associated with Olfactory Dysfunction in Patients with Chronic Rhinosinusitis

PURPOSE: Olfactory dysfunction (OD) is a debilitating symptom frequently reported by patients with chronic rhinosinusitis (CRS) and it is associated with a dysregulated sinonasal inflammation. However, little information is available about the effect of the inflammation-related n...

2023-05-12 | MTBLS7584 | MetaboLights
MetabolomicsCholic Acid as a Potential Mediator in PD Olfactory Dysfunction: Insights from Nasal Microbiome-Metabolite Interactions Research

Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by both motor and non-motor symptoms, including olfactory dysfunction, which often precedes motor symptoms by several years. However, the underlying mechanisms linking olfactory dysfunction in PD to bio...

2025-07-07 | MTBLS12692 | MetaboLights
ProteomicsSARS-CoV-2 infection causes transient olfactory dysfunction in mice
SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in human, and olfactory dysfunction represents as one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mechanism how SARS-CoV-2 infection leads to olfactory disorders remains elusive. Herei...
ORGANISM(S): Mus Musculus 
2021-06-22 | PXD026854 |
ProteomicsAcetylome Analyses Provide New Insights into the Effects of Childhood Allergic Rhinitis on Olfactory Bulb-Dependent Olfactory Impairment
Background: Allergic rhinitis (AR) is a global health burden affecting 20% of the pediatric population and is characterized by nasal inflammation and frequent olfactory dysfunction. Protein acetylation, which is a frequently occurring posttranslational modification, plays pivotal roles in the regula...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD066708 | Pride
Allergic rhinitis  children  olfactory dysfunction  olfactory bulb  lysine acetylation 
TranscriptomicsCOVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system
Describe the transcriptomic profile of Golden Hamster olfactory bulb in response to SARS-CoV-2 infection, separating by sexes.
ORGANISM(S): Mesocricetus auratus 
2021-06-19 | E-MTAB-10442 | biostudies-arrayexpress
ProteomicsA proteomic analysis of human olfactory bulb
Olfactory sensory neurons distinguish a large variety of odor molecules and direct the information through their axons to the olfactory bulb, the first site for the processing of olfactory information in the brain. Olfaction is very important for most mammals for the maintenance of a good quality of...
ORGANISM(S): Homo sapiens (Human) 
2017-08-23 | PXD005629 | Pride
Tissue Brplc Ltq-orbitrap Protein biomarkers Neuroproteomics. 
TranscriptomicsGenome-wide expression analysis of E18.5 and P30 olfactory bulbs of control and Tshz1 mutant mice
Analysis of genes regulated by Tshz1 in olfactory bulb neurons. Total RNA from olfactory bulbs of embryonic day E18.5 and postnatal day 30 control mice was compared to Tshz1 mutant mice
ORGANISM(S): Mus musculus 
2023-10-12 | E-GEOD-51761 | biostudies-arrayexpress
ProteomicsOlfactory proteomics in Parkinson disease
Olfactory dysfunction is one of the earliest features in Lewy-type alpha-synucleinopathies (LTS) such as Parkinson´s disease (PD). However, the underlying molecular mechanisms associated to smell impairment is poorly understood. To reveal the missing links in the biochemical understanding of olfacto...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD008036 | Pride
Proteomics Olfactory bulb Parkinson 
ProteomicsOlfactory bulb proteomics in human Alzheimer's disease
Olfactory dysfunction is among the earliest features of Alzheimer´s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis was performed across different AD stages using a label-free...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD005319 | Pride
Proteomics Olfactory bulb 
TranscriptomicsEpigenetic and transcriptional landscapes of Dnmt3a-deficient olfactory sensory neurons
During differentiation, neurons experience a reorganization of DNA modification patterns within their genomes. However, the mechanisms underlying this developmental patterning and its role in defining the neurona­­l state are currently unclear. Here, we find that the d­­e novo DNA methyltransfer...
ORGANISM(S): Mus musculus 
2014-11-05 | E-GEOD-52464 | biostudies-arrayexpress
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