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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsGlobal untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo beta-lactamase, MBLAC1
The C. elegans gene swip-10 encodes an orphan metallo beta-lactamase that genetic studies indicate is vital for limiting neuronal excitability and viability. Sequence analysis indicates that the mammalian gene Mblac1 is the likely ortholog of swip-10, with greatest sequence identity localized...
2019-03-12 | MTBLS650 | MetaboLights
ProteomicsOrphan quality control shapes network dynamics and gene expression
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb interactions between network components often result in disease, but how composition and dynamics of complex networks are established remains poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2023-05-30 | PXD041519 | Pride
Myc Dsso Ubr5 Proteasome Ubiquitin Orphan quality control Crosslinking 
GenomicsOrphan quality control shapes network dynamics and gene expression
Orphan quality control shapes network dynamics and gene expression
PRJNA980276 | ENA
MetabolomicsSexual Propagation Enhances Tea Quality Through Rhizosphere Microbiome Assembly and Metabolic Reprogramming in Camellia sinensis
Tea quality is primarily determined by the accumulation of specialized metabolites in fresh leaves; however, the mechanisms by which propagation methods influence tea qual-ity through plant–soil–microbiome interactions remain poorly understood. Here, sexually propagated (SR) and asexually propagated...
2026-08-05 | MTBLS15257 | MetaboLights
GenomicsOrphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons
Orphan quality control by an SCF ubiquitin ligase directed to pervasive C-degrons
PRJNA1032910 | ENA
ProteomicsHERC2 orchestrates assembly quality control of multimeric protein complexes via ubiquitylation of orphan subunits
Most eukaryotic proteins function as subunits within multimeric complexes. Imbalances in subunit levels disrupt assembly, leaving orphan proteins that are degraded by unclear quality control mechanisms. We identify the ubiquitin ligase HERC2 as a key regulator of this process. Proteomic analysis rev...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD071427 | Pride
Assembly quality control Multi-protein complexes Protein stability Ligase Bioub. Herc Proteasome Ubiquitin 
TranscriptomicsOrphan quality control shapes network dynamics and gene expression
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb interactions between network components often result in disease, but how composition and dynamics of complex networks are established remains poorly understo...
ORGANISM(S): Homo sapiens 
2023-06-07 | GSE234200 | GEO
TranscriptomicsTranscription profiling of mouse neural stem cell lines overexpressing Nurr1 to clonal controls
The orphan nuclear receptor Nurr1 has been shown to be critical for the development of ventral midbrain dopaminergic neurons. Consequently, the development of ES cells overexpressing Nurr1 has raised hope for the development of cell replacement therapies for Parkinson's Disease to replace degenerate...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3571 | biostudies-arrayexpress
UnknownBacterial rhomboid proteases mediate quality control of orphan membrane proteins.
Not available
S-EPMC7232013 | biostudies-literature
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