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MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsReplacing skeletal muscle alpha-actin with cardiac actin in mouse skeletal muscle
Skeletal muscle actin mice (Crawford et al., (2002) Mol Cell Biol 22, 5587) were crossed with cardiac actin transgenic mice (termed "ACTC^Coco" or "Coco" for short), to produce mice that had cardiac actin instead of skeletal muscle actin in their skeletal muscles (termed "AC...
ORGANISM(S): Mus musculus 
2009-05-24 | E-GEOD-12882 | biostudies-arrayexpress
TranscriptomicsActin Cytoskeleton Integrates Auxin and Brassinosteroid Signaling in Plants.
We describe a new mutant allele of the ACTIN2 gene with enhanced actin dynamics, displaying a broad array of twisting and bending phenotypes that resemble BR-treated plants. Moreover, auxin transcriptional regulation is enhanced on the mutant background, supporting the idea that shaping actin filame...
ORGANISM(S): Arabidopsis thaliana 
2012-11-21 | E-GEOD-27077 | biostudies-arrayexpress
ProteomicsN-terminal processing of beta and gamma actin in human platelets
Actin is one of the most essential and abundant intracellular proteins, playing an essential physiological role as the major constituent of the actin cytoskeleton. Two cytoplasmic actins, beta- and gamma-actin, are encoded by different genes, but their amino acid sequences differ only by four conser...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032086 | Pride
Actin Human Platelet 
ProteomicsPurification of Human β and γ Actin from Budding Yeast
To facilitate biochemical studies of human cytoplasmic actins, Saccharomyces cerevisiaestrains were developed that express either human β-actin or γ-actin as their sole actin. Actins purified from these strains have biochemical properties similar to mammalian skeletal muscle α-actin, but display di...
ORGANISM(S): Oryctolagus sp. 'Rabbit_OD' Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-04-24 | PXD040174 | Pride
Β-actin Cytoplasmic actin Non-muscle actin Γ-actin 
ProteomicsN-terminal processing of beta and gamma actin in MEF cells
Actin is one of the most essential and abundant intracellular proteins, playing an essential physiological role as the major constituent of the actin cytoskeleton. Two cytoplasmic actins, beta- and gamma-actin, are encoded by different genes, but their amino acid sequences differ only by four conser...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD032139 | Pride
Mouse Mef Actin 
ProteomicsN-terminal processing of beta and gamma actin in HAP1 cells
Actin is one of the most essential and abundant intracellular proteins, playing an essential physiological role as the major constituent of the actin cytoskeleton. Two cytoplasmic actins, beta- and gamma-actin, are encoded by different genes, but their amino acid sequences differ only by four conser...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031481 | Pride
Actin Human Hap1 
TranscriptomicsThe nuclear actin-related protein Arp6 contributes to the radial positioning of chromosome territories.
The chromatin of individual chromosomes is organized into chromosome territories (CTs) in the interphase nucleus. The spatial arrangement of CTs is non-random and evolutionarily conserved. The gene-dense and gene-poor CTs are positioned in the nuclear center and periphery, respectively. As candidate...
ORGANISM(S): Gallus gallus 
2015-11-04 | E-GEOD-14220 | biostudies-arrayexpress
TranscriptomicsLoss of the actin remodeler Eps8 causes calorie restriction and improved metabolic status in mice
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced bodyweight, partia...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-14454 | biostudies-arrayexpress
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