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MetabolomicsLandscape of gut microbiota and metabolites and their interaction in comorbid heart failure and depressive symptoms: a random forest analysis study

Depression is an individual risk factor for poor prognosis in patients with heart failure (HF). Recent studies show that gut microbiota and metabolites have critical role in comorbid HF and depressive symptoms. We recruited 95 subjects including 35 HF patients with depressive symptoms (HF-DS), 36...

2023-10-23 | MTBLS8183 | MetaboLights
ProteomicsViperin Mediates Coxsackievirus B3-induced Acute Heart Failure via KCNQ1 Ion Channel
Given that CVB3 is able to impair myocardial contractility, which finally leads to acute heart failure (AHF) and even sudden death, we tried to analyze the related myocardial function of these groups of mice
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD036898 | Pride
Viperin  cvb3  acute heart failure  sgk1 
ProteomicsDigestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients
Heart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence in acute multiorgan failure suggests that active digestive enzymes leak out of the small intestine into the systemic circulation and cause ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD026332 | Pride
Heart failure Free peptides Digestive enzymes Proteomics 
MetabolomicsAnalysis of human urine reveals metabolic changes related to the development of acute kidney injury following cardiac surgery
In an effort to identify novel biomarkers capable of predicting the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB) use, urine specimens were collected before and at 4 and 24 hours after surgery from 106 patients and analyzed by means of nuclear magne...
2012-10-21 | MTBLS24 | MetaboLights
TranscriptomicsGene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure
Heart failure (HF) is the most common cause of morbidity and mortality in the developed countries, especially considering the present demographic tendencies in those populations. We identified biologically relevant transcripts that are significantly altered in the early phase of myocardial infarctio...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-59867 | biostudies-arrayexpress
TranscriptomicsEffects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche (Human Data)
We demonstrate an age-independent loss of type H bone endothelium in heart failure after myocardial infarction in both mice and in humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium showing increased expression of inflammatory ge...
ORGANISM(S): Homo sapiens 
2021-05-11 | E-MTAB-10432 | biostudies-arrayexpress
TranscriptomicsIdentification of cell-intrinsic effects of clonal hematopoiesis in heart failure
Clonal hematopoiesis of indeterminate potential (CHIP) is caused by somatic mutations in hematopoietic stem cells and is associated with worse prognosis in heart failure patients. Patients harboring CHIP mutations show enhanced inflammation. However, whether these signatures are derived from the rel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-13016 | biostudies-arrayexpress
TranscriptomicsEffects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche (Mouse Data)
We demonstrate an age-independent loss of type H bone endothelium in heart failure after myocardial infarction in both mice and in humans. Using single-cell RNA sequencing, we delineate the transcriptional heterogeneity of human bone marrow endothelium showing increased expression of inflammatory ge...
ORGANISM(S): Mus musculus 
2021-05-13 | E-MTAB-10448 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hearts from DTG-positive mice before and after the induction of the transgene Akt1 at different time points to investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure
To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, a tetracycline-regulated transgenic system to conditionally switch a constitutively-active form of the Akt1 protein kinase on or off in the adult heart was developed. Short-term activation (2 we...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3383 | biostudies-arrayexpress
ProteomicsIdentifying candidate protein markers of acute kidney injury in acute decompensated heart failure using sheep kidney cortex
A quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI), an abrupt loss of kidney function that doubles the risk of death at one-year. There is a critical need to identify early markers for AKI in ADHF, however, no protein candidates have been validat...
ORGANISM(S): Ovis aries 
2022-01-19 | PXD028983 | Pride
Adhf Kidney Sheep Swath-ms Tripletof Acute kidney injury 
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