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ProteomicsProteome variation with collagen yield in ancient bone
Isotope analyses are some of the most common analytical methods applied to ancient bone, aiding the interpretation of past diets and chronology. For this, the evaluation of “collagen” yield is a routine step that allows for the selection of the specimens that are adequate for subsequent analyses, an...
ORGANISM(S): Bos taurus (Bovine) Cervus elaphus (Red deer) Homo sapiens (Human) Equus caballus (Horse) 
2021-02-08 | PXD020516 | Pride
Proteomics  ancient bone  collagen  ncps  radiocarbon dating  stable isotopes. 
MetabolomicsAlcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights
ProteomicsMolecular insights into an ancient form of Paget disease of bone
Paget disease of bone (PDB) is a chronic skeletal disorder with contemporary cases characterised by one or a few affected bones in individuals over 55 years of age. PDB-like changes have been noted in archaeological remains as old as Roman although accurate diagnoses and knowledge of the natural his...
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD011743 | Pride
Paget disease Paleoproteomics Sqstm1 P62 Osteosarcoma 
MetabolomicsExamination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions
Metabolomics is a modern tool that aids in our understanding of the molecular changes in organisms. Archaeological science is a branch of archaeology that explores different archaeological materials using modern analytical tools. Human osteoarchaeological material are a frequent finding in archaeolo...
2022-07-04 | MTBLS4437 | MetaboLights
ProteomicsBone proteomics methods optimisation for forensic investigations
The application of human bone in forensic proteomics is an expanding novel purpose in the aim of successfully quantifying biological estimations used in medico-legal investigations with greater accuracy. In this project, different extraction protocols were tested on n=30 human bone samples, includi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-10 | MSV000093803 | MassIVE
GenomicsMolecular insights into an ancient bone disorder
Molecular insights into an ancient bone disorder
PRJNA485979 | ENA
ProteomicsAncient proteins identify various Denisovan remains from Southwest China
Two parietal and one radius fragmentary hominin bones were identified from a systematical morphological prescreening of ~60,000 mammalian bone fragments and subsequent ZooMS analysis at Bianfu Cave in Yunan, Southwest China. Combined with two hominin teeth discovered during the excavation, all the f...
ORGANISM(S): Homo sapiens (Human) 
2026-07-24 | PXD073112 | Pride
Lc ms/ms Archaic human Bone 
GenomicsMolecular insights into an ancient bone disorder
DE microRNAs between normal bone and ancient osteosarcoma
ORGANISM(S): Homo sapiens 
2019-06-21 | GSE118540 | GEO
ProteomicsProteomic profiling of archeological human bone
We performed shotgun proteomics of human remains using rib bones from the Hitotsubashi site (1657–1683 AD) in Tokyo, called Edo in ancient times. Two infants and six adults, including four elderly adults, were obtained from the skeletal collection of the Hitotsubashi site in Tokyo, Japan. The indiv...
ORGANISM(S): Homo sapiens (Human) 
2017-06-08 | PXD006256 | Pride
Bone Human Edo period Ancient proteins 
TranscriptomicsSingle-cell RNAseq of human bone marrow cells enriched using RNA probes
Gene expression profiles of individual bone marrow cells were acquired by Drop-Seq. Subsets of bone marrow cells were isolated using fluorescence-assisted cell sorting to enrich for putative skeletal stem cells.
ORGANISM(S): Homo sapiens 
2022-05-31 | E-MTAB-9664 | biostudies-arrayexpress
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