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TranscriptomicsRole of Apollon in human melanoma resistance to anti-tumor agents that activate the intrinsic or the extrinsic apoptosis pathways
PURPOSE: To assess the role of Apollon in melanoma resistance to intrinsic and extrinsic pathways of apoptosis and to identify strategies to reduce its expression. EXPERIMENTAL DESIGN: Expression of Apollon was assessed in melanoma cell lines and in surgical specimens.Gene expression profiling, m...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-34686 | biostudies-arrayexpress
UnknownThe Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents.
Not available
S-EPMC7100275 | biostudies-literature
ProteomicsCD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
CD137 (4-1BB) is a member of the TNFR family that mediates potent T-cell costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic antitumor effects in cancer mouse models and multiple agents of this kind are undergoing clinical trials. W...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042585 | Pride
4-1bb Smac mimetic compounds Cd137 Ciap1 Ciap2 Immunotherapy 
TranscriptomicsTranscriptional profiling of wild type Neurospora crassa cells treated with novel antifungal agents
Purpose: Evaluate the transcriptional profile of Neurospora crassa cells treated with a group of novel antifungal compounds Methods: Conidial suspensions were obtained and 1 x 106 cells/ml incubated in minimal medium for 6 hours (26ºC, 140 rpm, constant light) followed by the addition of the indica...
ORGANISM(S): Neurospora crassa 
2015-11-25 | E-GEOD-53040 | biostudies-arrayexpress
TranscriptomicsAntitumor Activity of the Novel Flavonoid Oncamex in Preclinical Breast Cancer Models
Introduction: The flavonoid myricetin has been shown to induce cell cycle arrest and mitochondrial-dependent apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with redox properties and improved physicochemical attributes that enhance cell uptake and mitochondr...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-70949 | biostudies-arrayexpress
UnknownDiscovery of novel antitumor antimitotic agents that also reverse tumor resistance.
Not available
S-EPMC3858178 | biostudies-literature
UnknownDevelopment of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
Not available
S-EPMC7812702 | biostudies-literature
UnknownConjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.
Not available
S-EPMC4136547 | biostudies-literature
UnknownTargeted genome mining for microbial antitumor agents acting through DNA intercalation.
Not available
S-EPMC10413001 | biostudies-literature
UnknownData-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
Not available
S-EPMC6894422 | biostudies-literature
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