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Proteomicsabdominal aortic aneurysm (AAA) proteomics
An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD067859 | Pride
Dia-ms Human tissue Abdominal aortic aneurysm 
ProteomicsA Standard Operating Procedure for Protein Extraction from Abdominal Aortic Aneurysm Tissue: Enhancing Proteomics Applications
The identification of putative biomarkers for predicting abdominal aortic aneurysm (AAA) progression can be achieved through proteomic strategies, particularly with shotgun proteomics. However, the heterogeneity of AAA tissue poses challenges for tissue homogenization and protein extraction, comprom...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060417 | Pride
Abdominal aortic aneurysm  aortic tissue homogenization  protein extraction  proteomics  sop 
ProteomicsMouse and human abdominal aneurysm proteomics
Aortic tissues of developing and established aneurysms produced by angiotensin II (AngII) infusion were examined in Apoe-/- and Ldlr-/- mice. Aortas were also acquired from wildtype C57BL/6J mice following intraluminal elastase incubation. Aortas were dissected free and separated into eight anatom...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-02 | PXD032293 | Pride
Fermt3 Co-regulation Mass spectrometry 
TranscriptomicsTranscription profiling of mouse treated by ascending aortic banding on wild type and transgenic mice overexpressing CHF1/Hey2 in the myocardium reveals CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload
We have previously found that overexpression of CHF1/Hey2 in the myocardium prevents the development of phenylephrine-induced hypertrophy. To determine the role of CHF1/Hey2 in pressure overload hypertrophy, we performed ascending aortic banding on wild type and transgenic mice overexpressing CHF1/H...
ORGANISM(S): Mus musculus 
2010-02-17 | E-GEOD-13031 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human heart characterizing the progression of heart failure in patients with aortic valve stenosis
Myocardial left ventricular biopsies from male patients (n=6) with isolated aortic stenosis and pronounced left ventricular hypertrophy undergoing aortic valve replacement were harvested either from hearts with normal ejection fraction (EF,>50%) or with low EF (<30%). Biopsies were further obtained ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-MEXP-2296 | biostudies-arrayexpress
ProteomicsCharacterization of the human myocardial phosphoproteome in aortic stenosis patients with complete or incomplete reverse remodeling
Aortic valve stenosis (AS) is a serious condition characterized by the progressive narrowing of the aortic valve, associated with a continuous rise in left ventricle pressure overload. Currently, aortic valve replacement (AVR) remains as the definitive treatment for AS, since an immediate dissipatio...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD015498 | Pride
Human  phosphoproteome  myocardium  aortic stenosis  reverse remodeling 
ProteomicsCharacterization of the human myocardial proteome in aortic stenosis patients with complete or incomplete reverse remodeling
Aortic valve stenosis (AS) is a serious condition characterized by the progressive narrowing of the aortic valve, associated with a continuous rise in left ventricle pressure overload. Currently, aortic valve replacement (AVR) remains as the definitive treatment for AS, since an immediate dissipatio...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD015497 | Pride
Human  proteome  myocardium  left ventricle  aortic stenosis  reverse remodeling 
UnknownA Standard Operating Procedure for Protein Extraction From Abdominal Aortic Aneurysm Tissue: Enhancing Proteomics Applications.
Not available
S-EPMC12743587 | biostudies-literature
UnknownOptimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure.
Not available
S-EPMC9505568 | biostudies-literature
TranscriptomicsThe atlas of the human hypertrophied heart reveals impaired cell communication
Pathological cardiac hypertrophy is a leading cause of heart failure. The understanding of disease mechanisms is primarily based on experimental models, but knowledge of the full repertoire of cardiac cells and their gene expression profiles in the human heart is missing. Here, using large-scale sin...
ORGANISM(S): Homo sapiens 
2021-12-06 | E-MTAB-11268 | biostudies-arrayexpress
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