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ProteomicsAlzheimer’s disease risk and the isoform dependence of phospholipid-apolipoprotein E interaction
The ε4 allele of the APOE gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer’s disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary f...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD068681 | Pride
Csp Proteomics Ms Apoe Lipids Plasmalogen 
ProteomicsMetrologically traceable quantification of three apolipoprotein E isoforms in cerebrospinal fluid
Apolipoprotein E (apoE) is a 317-amino-acid long glycoprotein with three common isoforms (apoE2, apoE3, and apoE4) encoded by three apoE alleles (ε2, ε3, and ε4). These polymorphic forms arise from single amino acid substitutions with Cys and Arg interchanged at positions 112 and 158 (mature protein...
ORGANISM(S): Homo Sapiens 
2023-06-13 | PXD038803 | panorama
TranscriptomicsMicroarray gene expression profiling of heart failure induced in apolipoprotein E-deficient mice by treatment with rosiglitazone
The anti-diabetic drug and agonist of the peroxisome proliferator-activated receptor gamma (Pparg), rosiglitazone, was recently withdrawn in many countries because the drug use was associated with an increased risk of heart failure. To investigate underlying pathomechanisms, we chose 6-month-old apo...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-28031 | biostudies-arrayexpress
GenomicsApolipoprotein A-I Influences The Transcriptional Profile Of Fatty Liver In Apolipoprotein E Knockout Mice
Apolipoprotein A-I Influences The Transcriptional Profile Of Fatty Liver In Apolipoprotein E Knockout Mice
PRJNA1146900 | ENA
GenomicsThe effect of apolipoprotein E on asthmatic bronchial brushing cell gene signature
The effect of apolipoprotein E on asthmatic bronchial brushing cell gene signature
PRJNA527849 | ENA
TranscriptomicsA 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared to cigarette smoke.
Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has been paid to the reduced harm potential of alternative nicotine-containing inhalable products such as e-cigarettes. We investigated the effects of E-vapor aerosols or cigarette smoke (CS) on atherosclerosis progre...
ORGANISM(S): Mus musculus 
2020-05-12 | E-MTAB-8578 | biostudies-arrayexpress
TranscriptomicsApolipoprotein E promotes invasion in oral squamous cell carcinoma
Genome-wide expression array measurements for 9 head and neck squamous cell carcinomas (HNSCC) stratified by worst pattern of invasion (WPOI) Jayakar et al. (2016). Apolipoprotein E promotes invasion in oral squamous cell carcinoma. Li et al. (2013). Validation of the risk model: high-risk classif...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-79795 | biostudies-arrayexpress
GenomicsRNAseq analysis of Angiotensin II or PBS perfused Apolipoprotein E deficient mice
RNAseq analysis of Angiotensin II or PBS perfused Apolipoprotein E deficient mice
PRJNA594531 | ENA
TranscriptomicsProtective role of Apolipoprotein E in experimental acute renal allogaft rejection
Objective: Apolipoprotein E (Apo E) is a multifunctional protein, originally described in the context of lipoprotein metabolism and cardiovascular disease. More recently, anti-inflammatory functions of ApoE have been documented. ApoE was studied in the context of several inflammatory disorders, but ...
ORGANISM(S): Rattus norvegicus 
2016-06-01 | E-GEOD-58156 | biostudies-arrayexpress
TranscriptomicsInterleukin-7 promotes monocyte/macrophage arrest on endothelial cells
Background: It is recognized that atherosclerosis can regresses at least in animal models. However, little is known about the mechanisms. We induced regression of advanced atherosclerosis in apolipoprotein E deficient (APOE­/­) mice and studied underlying mechanisms. Unexpectedly, our study led to t...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-15914 | biostudies-arrayexpress
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