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MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
MetabolomicsMacrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, ...
2021-03-05 | MTBLS2159 | MetaboLights
MetabolomicsIntegrated Proteomics and Metabolomics Analyses Revealed Potential Phospholipid-Related Biomarkers in Rabbit Atherosclerotic Plaques

BACKGROUND AND AIMS: Atherosclerosis, characterized by dysfunction of lipid metabolism and chronic inflammation, is considered as a metabolic disorder as well as a major contributor to cardiovascular diseases. However, metabolic signatures of atherosclerosis have not been well ex...

2024-09-26 | MTBLS9737 | MetaboLights
ProteomicsMolecular Landscape of Atherosclerotic Plaque Progression: Insights from Proteomics
This dataset comprises proteomic profiles of 87 human carotid atherosclerotic plaques from patients undergoing carotid endarterectomy (CEA). The study employed an integrated approach using Data Independent Acquisition (DIA) proteomics. A total of 87 human carotid plaques were analyzed to identify an...
ORGANISM(S): Homo Sapiens 
2025-03-26 | PXD062283 |
TranscriptomicsMouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations
The single-cell RNA-seq experiment aims to explore the cell-type composition of right coronary artery plaques to provide an overview of human-like atherosclerosis. The PCSK9 transgenic minipigs were subjected to 15 months of HFHC diet (HFHC group f, n=4; m, n=1). At the time of euthanasia, plaque pa...
ORGANISM(S): Sus scrofa 
2025-08-30 | E-MTAB-15464 | biostudies-arrayexpress
ProteomicsProteomic analysis of human atherosclerotic plaque supernatants in response to treatment with monocyte extracellular vesicles
Extracellular vesicles (EV) convey biological messages through their cargoes. Herein we focus on monocyte/platelet aggregates characteristic of several cardiovascular diseases with an analysis of monocyte-derived EV (mEVs) effects on the atherosclerotic plaque. Monocyte preparations were stimulated ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD014324 | Pride
Extracellular vesicles Human atherosclerotic plaques 
ProteomicsUnstable Atherosclerotic Plaque Proteome
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, is a major health burden worldwide. Limited understanding as to the molecular drivers of plaque instability and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Utilisin...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD030857 | Pride
Atherosclerosis Therapeutic Mouse Plaque Proteome 
ProteomicsMulti-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, are a major health concern worldwide. Limited understanding as to the molecular drivers of plaque destabilisation and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Us...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-24 | PXD018224 | Pride
Atherosclerosis Mouse Plaque Thrombosis 
TranscriptomicsGenes in unstable plaques
Transcriptional profiling of stable and unstable atherosclerotic plaque segments from human carotid endatrerectomies Objective Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study was to identify differen...
ORGANISM(S): Homo sapiens 
2006-01-30 | E-TABM-190 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human atherosclerotic plaque
This SuperSeries is composed of the following subset Series: GSE23303: Gene expression profiling of human atherosclerotic plaque: Laser capture microscopy of smooth muscle cells and macrophages GSE23304: Gene expression profiling of human atherosclerotic plaque: 101 peripheral plaques GSE24495: Gene...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-23314 | biostudies-arrayexpress
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