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TranscriptomicsATM-deficient B cell lymphomas
Ataxia-telangiectasia mutated (ATM) kinase plays a central role in maintaining genomic integrity. In both humans and mice, ATM deficiency is associated with an increased incidence of lymphoid cancers that are primarily T cell in origin. We demonstrate here that when T cells are removed as targets fo...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-68505 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression in ATM-deficient MEFs
The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs. Nonirradiated-ATM-WT vs Irradiated-ATM-WT vs Nonirradaited-ATM-KO vs IrradiatedATM-KO
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-23116 | biostudies-arrayexpress
no omics definedTranscription profiling of wild type and Atm-/- mouse lymph nodes treated with ionizing radiation
The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a maste...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2118 | biostudies-arrayexpress
ProteomicsThe ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5
Ataxia telangiectasia mutated (ATM) is a protein that belongs to the family of phosphatidylinositol 3-kinase (PI3K)-like serine/threonine kinases. Initially identified as a nuclear protein essential for the DNA damage response (DDR) in mitotic cells, it serves as repair coordinator for DNA double-st...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-29 | PXD058394 | Pride
Taxol Sodium arsenite Coimmunoprecipitation Differential ultracentrifugation Label-free mass spectrometry Chloroquine Immobilized metal affinity chromatography Phosphoscan 
TranscriptomicsNon redundant functions of ATM and DNAPKcs in response to clean DNA Double Strand Breaks.
DNA Double Strand Breaks (DSBs) are harmful lesions that require rapid detection and repair in order to avoid toxic genomic rearrangements. DSBs elicit the so called DNA Damage Response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA Protein Kinase (DNAPK), two members of the P...
ORGANISM(S): Homo sapiens 
2015-09-30 | E-MTAB-2992 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ATM +/+, ATM +/- and ATM -/- human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients
Transcription profiling of ATM (Ataxia Telangiectasia Mutated) +/+ (Control), ATM +/- (AT Carrier) and ATM -/- (AT patient) human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients
ORGANISM(S): Homo sapiens 
2008-07-29 | E-TABM-321 | biostudies-arrayexpress
TranscriptomicsATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
Analysis of the effects of ATM loss on gene expression to identify causes of neurodegeneration. ATM levels were reduced ubiquitously via the temperature-sensitive ATM^8 allele, or via tissue-specific RNAi of ATM (ATMi) using the Gal4/UAS expression system in neurons (Elav-GAL4 and ElavC155-GAL4) or...
ORGANISM(S): Drosophila melanogaster 
2011-12-10 | E-GEOD-34315 | biostudies-arrayexpress
ProteomicsTargeted mass spectrometry enables quantification of novel pharmacodynamic biomarkers of ATM kinase inhibitors
ATM is a serine/threonine protein kinase that is responsible for initiation of DNA repair of double-stranded breaks and is a therapeutic target in cancer. A lack of analytically robust and multiplexed assays has hampered mechanistic studies of action and determination of optimal, robust pharmacodyna...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD026103 | Pride
Human Lymphoblast Atm Phosphorylation 
TranscriptomicsTranscription profiling by array of ATM deficient human mammary epithelial cells
Deficiencies in the ATM gene are the underlying cause for ataxia telangiectasia, a congenital syndrome characterized by neurological, motor and immunological defects, as well as a predisposition to cancer risks. MicroRNAs (miRNAs) are small regulators of post-transcriptional gene expression and a us...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-36082 | biostudies-arrayexpress
TranscriptomicsWIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation
WIP1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. Here we found that WIP1 plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences in germ-line and cancer cells. WIP1 was required for ...
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-46103 | biostudies-arrayexpress
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