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GenomicsSS18-SSX-mediated hijacking of BAF complexes drives synovial sarcoma
Synovial sarcoma (SS) is defined by a recurrent t(x;18) chromosomal translocation, which produces the hallmark SS18-SSX oncogenic fusion. Incorporation of SS18-SSX into BAF complexes renders BAF complexes aberrant in two distinct manners: the addition of 78aa of SSX onto SS18, and concomitant loss o...
EGAS00001002920 | EGA
GenomicsmSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIa
Recent exon sequencing studies of human tumors have revealed that subunits of mSWI/SNF or BAF complexes are mutated in more than 20% of human malignancies, yet the mechanisms involved in tumor suppression is unclear. BAF chromatin remodeling complexes are polymorphic assemblies that use energy provi...
ORGANISM(S): Mus musculus 
2013-03-30 | E-GEOD-45625 | biostudies-arrayexpress
ProteomicsSynaptic Activity Causes Minute-scale Changes in BAF Complex Composition and Function
Genes encoding subunits of the SWI/SNF or BAF ATP-dependent chromatin remodeling complex are among the most enriched for deleterious de novo mutations in intellectual disabilities and autism spectrum disorder, but the causative molecular pathways are not fully known1,2. Synaptic activity in neurons ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD046031 | Pride
Baf200/arid2 Chromatin remodeling Swi/snf Baf 
ProteomicsA structural model of the human mSWI/SNF (BAF) complex bound to the nucleosome informs disease mechanisms
Mammalian SWI/SNF complexes are multi-component ATP-dependent chromatin-remodeling complexes that regulate genomic architecture. Here we present the first structural model of the human canonical BAF chromatin-remodeling complex bound to a nucleosome generated using cryo-EM, cross-linking mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD020992 | Pride
Homology model Cryo-em Atp-dependent chromatin remodeling Nucleosome acidic patch Yeast swi/snf Mammalian swi/snf Canonical baf complex Human disease Mutations 
ProteomicsAcute BAF perturbation causes immediate changes in chromatin accessibility
Loss-of-function mutations in genes coding for subunits of the large, multifarious BRG1/BRM associated factor (BAF) chromatin remodeling complexes are frequently causative for cancer or developmental diseases1-5. Cells lacking the most frequently mutated subunits like the ATPase SMARCA4 typically ex...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD018381 | Pride
Atac-seq Enhancer Dtag knock-in Chromatin remodeling Baf complex Chromatin accessibility Acute chemical degradation Synthetic lethality Mammalian swi/snf complex Kinetics 
ProteomicsA non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
The mammalian BRG1-associated factors (BAF) complex is a multi-subunit chromatin remodeling complex that is an important component of the embryonic stem cell (ESC) transcriptional regulatory network. However, the role of individual subunits in BAF complex targeting and function needs to be elucidate...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010670 | Pride
Baf Chromatin remodeling 
GenomicsBinding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. [RNA-seq]
Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. [RNA-seq]
PRJNA434202 | ENA
GenomicsBinding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis.[ChIP-seq]
Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis.[ChIP-seq]
PRJNA434201 | ENA
ProteomicsMudPIT analyses of the proteins co-purified with components of the LSD1 (KDM1A) transcriptional repressor complex and the non-canonical BAF complex, immuno-precipitated from MKL-1 and WaGa MCC cell lines
Protein Complexes Purification: Immunoprecipitations were performed with antibodies to LSD1 (2139; Cell signaling technology), INSM1 Mouse (SC-271408, Santa Cruz Biotechnology), RCOR2 (23969-1-AP; Proteintech Group), BRD9 (61537; Active Motif Rabbit), and normal Rabbit IgG (2729; Cell signaling tech...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-25 | MSV000083364 | MassIVE
GenomicsBCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation.
PRJNA867373 | ENA
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