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TranscriptomicsRadiation-induced bystander effects and gene expression in cells deficient for RAD9
Background: The radiation bystander response is an important component of the overall response of cells to radiation and critical to understanding health risks of radiation exposure to humans. The mechanism of radiation response includes inter-cellular signaling and intra-cellular communication by w...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-55869 | biostudies-arrayexpress
TranscriptomicsNormal human fibroblast cell line bystander effects by Carbon ion irradiation
We have recently investigated the response of irradiated and bystander fibroblasts to heavy ions in confluent cultures exposed randomly to broadbeam and selectively to precision microbeam that target a predefined fraction of cells with counted number of particle(s), respectively, and found the diffe...
ORGANISM(S): Homo sapiens 
2008-09-02 | E-GEOD-8993 | biostudies-arrayexpress
TranscriptomicsIMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the contribution of genome level changes in neighboring bystander cells to tissue and organ stress after irradiation. The timing of these ...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21059 | biostudies-arrayexpress
TranscriptomicsIMR90 4hr bystander experiment 0.5Gy alpha particle strip dish format
Radiation affects tissue and cellular integrity at the level of DNA, protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and tissue and radiation induced bystander effects are significant to exposed individuals in accidental or ...
ORGANISM(S): Homo sapiens 
2008-12-28 | E-GEOD-12435 | biostudies-arrayexpress
TranscriptomicsGenome-wide microarray analysis of immortalized human fibroblasts in response to alpha-particle radiation and the radiation induced bystander effect
The bystander effect from ionizing radiation consists of cellular responses generated from unirradiated cells to the irradiation of their neighbors. The bystander effect can lead to DNA damage and genomic instability in the affected cells. This non-targeted effect of radiation has received attention...
ORGANISM(S): Homo sapiens 
2011-09-13 | E-GEOD-32091 | biostudies-arrayexpress
TranscriptomicsIMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. It raises concerns for the interpretation of risks from exposure to low doses of ionizing radiation. Sparse data exists about the bystander signaling mechanisms...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-18760 | biostudies-arrayexpress
TranscriptomicsGenome-wide microarray analysis of normal human fibroblasts in response to γ-radiation and the radiation induced bystander effect
The bystander effect from ionizing radiation consists of cellular responses generated from non-irradiated cells to the irradiation of their neighbors. The bystander effect is predominant at low doses and can lead to DNA damage and genomic instability in the affected cells. This non-targeted effect o...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-25772 | biostudies-arrayexpress
ProteomicsProteomic analysis of bystander effects induced by irradiated chondrosarcoma cells
To understand the cellular response of bystander cells, we performed a 2D gel-based proteomic study of the chondrocyte receiving the conditioned medium of low dose irradiated chondrosarcoma cells. The proteomic analysis of the bystander chondrocytes highlighted 20 proteins spots that were significan...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD025187 | Pride
Proteomic analysis Chondrosarcoma Bystander signalling Secretome 
ProteomicsProteomic analysis of cold atmospheric plasma induced bystander signalling in human lung carcinoma A549 cells. S Nishad, PhD, Ghosh Somnath, PhD., and Ghosh Anu*, PhD. Radiation Biology & Health Sciences Division, Bio-Sciences Group, Bhabha Atomic Research Centre, Mumbai 400 085, India *Email: anugh@barc.gov.in
The radiation-induced bystander effect is defined by the presence of biological effects in cells that were not themselves in the field of irradiation. Plasma, as the fourth state of matter contains numerous active components including photons, free radicals, mild heat, electrons and ions. Cold atmos...
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD043888 | Pride
Bio-sciences group Phd India *email: anugh@barc.gov.in Mumbai 400 085 Proteomic analysis of cold atmospheric plasma induced bystander signalling in human lung carcinoma a549 cells. s nishad Phd. Phd. radiation biology & health sciences division And ghosh anu* Bhabha atomic research centre Ghosh somnath 
ProteomicsRadiation-induced bystander effect mediated by exosomes involves the replication stress in recipient cells.
Exosomes released by irradiated cells mediate radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells, yet the specific mechanism responsible for generation of chromosome lesions remains unclear. In this study, naïve FaDu head and neck cancer cells were stim...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD032143 | Pride
Bystander effect  exosomes  ionizing radiation  non-targeted effects of radiation  replication stress 
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