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MetabolomicsBacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show that the enzyme cystathionine γ-lyase (CTH) is induced in macrophages infected with pathogenic ba...

2020-05-15 | MTBLS696 | MetaboLights
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022956 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022954 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022888 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
UnknownOverexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3.
Not available
S-EPMC4749487 | biostudies-literature
MetabolomicsGlutaminolysis contribution to the carbon backbone of aspartate through ATP Citrate Lyase (ACLY) in ccRCC
Not available
ORGANISM(S): Homo sapiens 
ST002221 | MetabolomicsWorkbench
UnknownShort-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase.
Not available
S-EPMC8204489 | biostudies-literature
UnknownCatalytic specificity of the Lactobacillus plantarum cystathionine γ-lyase presumed by the crystallographic analysis.
Not available
S-EPMC7483736 | biostudies-literature
TranscriptomicsCystathionine γ-lyase downregulation contributes to hepatocyte injury and dysfunction via multiple signaling pathways by regulation of histone lysine methylation
Chronic liver disease (CLD) is prevalent globally. We sought to elucidate the molecular mechanisms governing the progress of CLD. We confirmed hepatic cystathionine γ-lyase (Cth) expression was significantly down-regulated in some CLDs. Therefore, we subsequently investigated the roles of Cth gene i...
ORGANISM(S): Mus musculus 
2024-10-17 | GSE279401 | GEO
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