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ProteomicsQuantitative profiling of protein sulfhydrome by the BTA-TMT
The redox-based modification of cysteine residues in proteins regulates their function in many biological processes. The gas molecule H2S has been shown to sulfhydrate redox sensitive cysteine residues resulting in an H2S-modified proteome known as the sulfhydrome. Tandem Mass Tags (TMT) multiplexin...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2020-03-09 | PXD015307 | Pride
Tmt Cysteine sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022956 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022954 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022888 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
UnknownDiscovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism.
Not available
S-EPMC7196587 | biostudies-literature
ProteomicsPersulfidation alters gene regulatory programs and promotes endothelial specification
Endogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown. Here we discovered that during directed differentiation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD071015 | Pride
Sulfide supplementation Endothelial commitment Persulfidation Stem cells 
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