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ProteomicsMCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially i...
ORGANISM(S): Homo sapiens (Human) 
2020-06-15 | PXD019156 | Pride
C17orf53 Mcm9 Mcm8 Mcm8ip Cisplatin Rpa Homologous recombination 
ProteomicsBiochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates
Crossing over between homologs is critical for the stable segregation of chromosomes during the first meiotic division. S. cerevisiae Mer3 (HFM1 in mammals) is a SF2 helicase and member of the ZMM group of proteins, that facilitates the formation of the majority of crossovers during meiosis. Here we...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD039839 | Pride
Crossover Yeast Phospho proteomics Meiosis Mer3 
OtherBidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer
Adenosine-to-inosine (A-to-I) RNA editing entails the enzymatic deamination of adenosines to inosines by adenosine deaminases acting on RNA (ADARs). Dysregulated A-to-I editing has been implicated in various diseases, including cancers. However, the precise factors governing the A-to-I editing and t...
ORGANISM(S): Homo sapiens 
2018-05-31 | GSE99789 | GEO
ModelsRaju2019 - Characterization of the phosphorylation site of GRTH and PKA binding
These are coordinates of an helicase and two variants known to affect spermatogenesis and potential target of novel non-hormonal oral male contraceptive
2026-10-11 | MODEL1904160001 | BioModels
ProteomicsThe RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly
Early pre-60S ribosomal particles are poorly characterized, highly dynamic complexes that undergo extensive rRNA folding and compaction concomitant with assembly of ribosomal proteins and exchange of assembly factors. Pre-60S particles contain numerous RNA helicases, which are likely regulators of a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022625 | Pride
Small nucleolar rna Ribosomal protein. Ribosome biogenesis Rna helicase 
ProteomicsRNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori
Ribonucleases are central players in post-transcriptional regulation, a major level of gene expression regulation in all cells. Here, we characterized the 3’-5’ exoribonuclease RNase R from the bacterial pathogen Helicobacter pylori. The "prototypical" Escherichia coli RNase R displays both exoribon...
ORGANISM(S): Helicobacter pylori B8 
2021-04-08 | PXD023837 | Pride
Ap-ms Proteomics Helicobacter pylori Q exactive plus 
ProteomicsIntrinsically Disordered Regions in Chromodomain Helicase DNA-binding (CHD) Proteins Shape Distinct Protein Interaction Networks
Metazoans employ chromodomain helicase DNA-binding (CHD) enzymes to reposition nucleosomal DNA for transcription and replication. The CHD family consists of nine distinct members (CHD1-9) that possess highly conserved chromo and ATPase domains. These domains are flanked by poorly characterised N- an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD055009 | Pride
Dna helicase Chromatin remodelers Transcription Intrinsically disordered regions Aggregation prone regions Protein-protein interactions 
TranscriptomicsRNA helicase DDX21 mediates nucleotide stress responses (PRO-Seq)
The RNA helicase DDX21 acts as trancriptional sensor for nucleotide lowering
ORGANISM(S): Homo sapiens 
2020-02-04 | GSE128081 | GEO
GenomicsRNA helicase DDX21 mediates nucleotide stress responses (ChIP-Seq)
The RNA helicase DDX21 acts as trancriptional sensor for nucleotide lowering
ORGANISM(S): Homo sapiens 
2020-02-04 | GSE128080 | GEO
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
PXD054574 |
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