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MetabolomicsPlant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens
Rice is a staple food crop worldwide, and its production is severely threatened by phloem-feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistanc...
2022-02-23 | MTBLS3518 | MetaboLights
TranscriptomicsDNA damage signaling gene array on SMA mouse skeletal muscle
A commercially available gene array (SABiosciences array PAMM-029ZD-12) was used to assay gene expression in skeletal muscle of SMA mice and control littermates. The Taiwanese severe SMA mouse model was used (Hsieh-Li et al. 2000). The array included 84 genes associated with DNA damage detection, DN...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-55481 | biostudies-arrayexpress
GenomicsQuantitative sensing and signalling of single-stranded DNA during the DNA damage response
Quantitative sensing and signalling of single-stranded DNA during the DNA damage response
PRJNA514440 | ENA
ProteomicsSystems-level phosphoproteomic and RPPA profiling reveals stress and DNA damage signalling as early drivers of polymyxin B neurotoxicity
Polymyxins remain indispensable last-line antibiotics for multidrug-resistant Gram-negative infections, yet their clinical use in central nervous system (CNS) infections is constrained by poorly understood neurotoxicity. Here, we define the early molecular signalling events underlying polymyxin B-in...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD075314 | Pride
Polymyxin b  neurotoxicity  central nervous system  phosphoproteomics  reverse phase protein array  apoptosis  dna damage signalling  antibiotic toxicodynamics. 
ProteomicsMaximizing Confidence and Sensitivity in Phosphoproteomics reveals novel targets of DNA damage signling Kinases
Proteome-wide analysis of phosphorylation events is a challenging, yet essential, task for the comprehensive and unbiased investigation of kinase action. Here we developed a phosphoproteomic approach in which quantitation consistency among reversed isotopically labeled samples is used as a central f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2020-01-24 | MSV000084839 | MassIVE
TranscriptomicsTranscription profiling of human fibroblasts subjected to DNA damage reveals ATM-dependent regulation of gene expression
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6971 | biostudies-arrayexpress
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
TranscriptomicsDNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo
Activation of the MLL-ENL-ERtm oncogene initiates aberrant proliferation of myeloid progenitors. Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21 checkpoint and cellular senescence at earl...
ORGANISM(S): Mus musculus 
2012-04-21 | E-GEOD-35038 | biostudies-arrayexpress
ProteomicsSensing and signalling of DNA breaks in extracts of preblastoderm Drosophila embryos
Preblastoderm Drosophila embryos replicate their genomes at maximal speed. The assembly of chromatin on the newly synthesized chromosomes relies entirely on high concentrations of maternal nucleosome assembly and remodelling factors. Extracts from preblastoderm embryos can be turned into a system fo...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-10-14 | PXD013130 | Pride
Dna repair Dna damage response D.melanogaster 
ProteomicsThe dynamics of Atm signalling dictate cellular fate decisions after DNA damage
DNA damage activates diverse cellular responses – either protective or deleterious –that ultimately promote or inhibit proliferation. How the distinct responses conferring crucial cell fate decisions are chosen is unclear. Using a systems approach, we demonstrate that the dynamic features of Atm...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD013620 | Pride
Phosphoproteomics Mdc1 Post-translational modification Mass spectrometry Mouse Ionizing radiation Biological Phosphorylation Lc-msms Mescs Atm Silac Signal transduction Chek2 
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