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ProteomicsA library of novel Cancer Testis specific T cell receptors for T cell receptor gene therapy
Background Clinical success of T cell receptor (TCR) gene therapy has previously been demonstrated for NY-ESO-1 TCR gene therapy. To increase numbers of cancer patients that can be treated with TCR gene therapy we aimed to identify a novel set of high-affinity cancer specific TCRs targeting differen...
ORGANISM(S): Homo sapiens (Human) 
2023-01-23 | PXD038862 | Pride
T cell receptor Tcr gene therapy Mage Cd8+ t cells Cancer testis genes 
ProteomicsSilencing mitochondrial gene expression in living cells – COX1-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061876 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
ProteomicsComparative gene and protein expression profile of olfactory ensheathing cells from olfactory bulb and olfactory mucosa
Olfactory ensheathing cells are one of the few central nervous system regenerative cells discovered so far. It is characterized by its lifelong nerve regeneration function, and it can also release a variety of neurotrophic factors and neural adhesion molecules. It is considered to be the glial cell ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD024046 | Pride
Olfactory ensheathing cells (oecs)  olfactory bulb (ob)  olfactory mucosa (om)  gene  protein  gene ontology (go)  kyoto encyclopedia of genes and genomes (kegg)  molecular function  cellular component  biological process 
ProteomicsPropensity for proto-gene emergence in bacteria
The birth of new genes from non-coding sequences has been postulated to be preceded by a proto-gene phase, in which a sequence is translated into protein but does not exhibit hallmarks of a clear function. Despite the abundance of such proto-genes in bacterial genomes, the frequency of their emergen...
ORGANISM(S): Escherichia coli Bacteria 
2025-09-19 | PXD062120 | Pride
Proto-genes Mass spectrometry Bacteria De novo gene evolution 
ProteomicsAn Orphan-Moonlighting Gene PRL-1 Enhances Photosynthetic Efficiency and Productivity in Plants
Increasing photosynthetic efficiency remains a major goal across the globe given its central role in CO2 assimilation. Here, we identified a nuclear genome-residing orphan gene, comprised of 3 exons, two with apparent endophytic origins and the third being a highly conserved fragment of the RIBULOSE...
ORGANISM(S): Populus Trichocarpa (ncbitaxon:3694) 
2023-04-24 | MSV000091785 | MassIVE
ProteomicsSilencing mitochondrial gene expression in living cells – CYTB- and ND2-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061846 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
ProteomicsDesign of a gene signature to assess the proinflammatory and the profibrotic polarization of murine fibroblasts
We provide an original multi-stage approach identifying a gene signature to assess the fibroblast polarization. Prototypic polarizations (inflammatory/fibrotic) were induced by seeded mouse embryonic fibroblasts (MEFs) with TNFα or TGFß1, respectively. The transcriptomic and proteomic profiles were ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-12 | PXD034078 | Pride
Inflammation-mediated fibrosis  fibrosis  fibroblast polarization 
ProteomicsPhototropin2 3'UTR overlaps with the AT5G58150 gene encoding an inactive RLK kinase
This study aimed to investigate the biological implications of two overlapping sequences in the Arabidopsis genome, the 3UTR of the PHOT2 gene and a putative AT5G58150 gene, encoded on the complementary strand. AT5G58150 is a probably inactive protein kinase that belongs to the transmembrane, leucin...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2022-12-21 | MSV000090945 | MassIVE
ProteomicsLipid nanoparticles improves ex vivo gene editing of human hematopoietic cells
Ex-vivo gene editing in T cells and hematopoietic stem/progenitor cells (HSPCs) holds promise for treating diseases by non-homologous end joining (NHEJ) gene disruption or homology-driven repair (HDR) gene correction. Gene editing encompasses delivery of nucleases by electroporation and, when aiming...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037529 | Pride
Hunan Nanoparticles Hematopoietic cells 
ProteomicsThe Functions of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo
This dataset includes BioID for SEC23A and SEC23B. The paper describes the functional redundancy of these two gene paralogs in the context of human disease.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081703 | MassIVE
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