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TranscriptomicsEffect of endoglin loss on embryoid bodies
Analysis of embryonic sten cell-derived embryoid bodies following endoglin knock out. Loss of endoglin leads to profound reduction of key hematopoietic regulators including SCL, LMO2, Gata2, and TGF-? signaling molecule ALK-1. Results provide insight into molecular mechanisms underlying hemangioblas...
ORGANISM(S): Mus musculus 
2011-05-16 | E-GEOD-29300 | biostudies-arrayexpress
TranscriptomicsEndoglin study 4, 20, 40 weeks 0 vs.16 Gy
Endoglin study 4, 20, 40 weeks 0 vs.16 Gy
ORGANISM(S): Mus musculus 
2013-06-15 | E-MTAB-1488 | biostudies-arrayexpress
TranscriptomicsBMP-2-responsive genes in mouse periodontal ligament-derived PDL-L2 cells with and without endoglin knockdown
This study was designed to identify endoglin (ENG)-dependent BMP2-responsive genes in the mouse fibroblastic cell line PDL-L2. PDL-L2 cells were treated with an siRNA for endoglin (siENG) or a control siRNA (siCont). After 48hr, the cells were exposed to recombinant human BMP-2 (250 ng/ml) or vehicl...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-54220 | biostudies-arrayexpress
ProteomicsEndoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners
Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause Hereditary Hemorrhagic Telangiectasia type 1, a vascular disease that present with nose and gastroint...
ORGANISM(S): Mesocricetus auratus (Golden hamster) Homo sapiens (Human) 
2019-09-25 | PXD015402 | Pride
Endothelial cells  endoglin  tgf-β  bmp  hht  cancer  preeclampsia  trim family  galectin family  protein-protein interactions 
TranscriptomicsGene expression signatures for fractions of E7.5 whole embryos based on Endoglin and Flk-1 markers
Much remains unknown about the signals that induce early mesoderm to initiate hematopoietic differentiation. Here we show that endoglin (Eng), a receptor for the TGFβ superfamily, identifies all cells with hematopoietic fate in the early embryo. These arise in an Eng+Flk1+ mesodermal precursor popu...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-37515 | biostudies-arrayexpress
ProteomicsCirculating endoglin induces hypertension via the upregulated expression of BMP4
Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and involved in cardiovascular diseases. Upon the proteolytic processing of the membrane-bound protein, a circulating form of endoglin (soluble endoglin, sEng) can be released, and high levels of sEng have been obser...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016228 | Pride
Tgf-β Endothelial cells Preeclampsia Hypertension Endoglin Hht Bmp4 
TranscriptomicsRNA-SEQ assay for wild type and CRISPR induced endoglin knockout human pulmonary artery smooth muscle cells (PASMC)
The goal of this study is to investigate the differential transcripted genes affected by CRISPR induced endoglin knockout in PASMC cells. Total RNA was purified from NTC or ENG-/- PASMC cells using RNeasy Mini Kit (Qiagen, Hilden, Germany). RNA quality and concentration were assessed with Agilent Ta...
ORGANISM(S): Homo sapiens 
2017-05-16 | E-GEOD-78271 | biostudies-arrayexpress
ProteomicsTMT-based quantitative proteomic analysis of serum from patients with postherpetic neuralgia reveals a key role of Endoglin in neuropathic pain via TGF-β/Smad2 signaling
This dataset comprises a Tandem Mass Tag (TMT)-based quantitative proteomic analysis of serum samples from patients with postherpetic neuralgia (PHN) compared to healthy control subjects. The study aimed to identify differentially expressed proteins involved in the pathogenesis of neuropathic pain. ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD067890 | Pride
Quantitative proteomics Endoglin (cd105) Neuropathic pain Tandem mass tag (tmt) Tgf-β/smad2 signaling Ostherpetic neuralgia (phn) Biomarker Blood-spinal cord barrier (bscb) 
GenomicsEndoglin regulates the integrity of the bone marrow vasculature
Endoglin regulates the integrity of the bone marrow vasculature
PRJNA1131347 | ENA
TranscriptomicsEffect of endoglin loss on embryoid bodies
Analysis of embryonic sten cell-derived embryoid bodies following endoglin knock out. Loss of endoglin leads to profound reduction of key hematopoietic regulators including SCL, LMO2, Gata2, and TGF-β signaling molecule ALK-1. Results provide insight into molecular mechanisms underlying hemangioblas...
ORGANISM(S): Mus musculus 
2011-05-16 | GSE29300 | GEO
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