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MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
MetabolomicsHistone H3K4me3 Demethylase RBP2 Transcriptionally Activates PPARγ to Drive Lipid Metabolic Reprogramming in Gastric Carcinoma

This work investigates epigenetic driven lipid metabolic reprogramming in gastric carcinoma. We characterize that histone H3K4me3 demethylase RBP2 transcriptionally activates PPARgama by binding to its promoter region,thereby promoting lipogenic gene expression and intracellular lipid accumulatio...

2026-08-14 | MTBLS15324 | MetaboLights
ProteomicsMining potential serum biomarkers for gastric adenocarcinoma using quantitative proteomics
Serum is a valuable body fluid to diagnose cancer as it can be accessed with minimal invasive techniques. Studying the cancer serum proteome provides valuable insights into the pathophysiology of tumor progression. Gastric adenocarcinoma is an aggressive cancer resulting in poor prognosis, mainly du...
ORGANISM(S): Homo sapiens (Human) 
2015-07-27 | PXD001265 | Pride
Serum biomarkers Gastric cancer Quantitative proteomics Adenocarcinoma 
TranscriptomicsSmall bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers
Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chr...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-23418 | biostudies-arrayexpress
MetabolomicsMetabolomics-based and functional validation to explore the effect of the gut microbe-associated metabolite guanidinoacetic acid on rectal adenocarcinoma

Objective: The gut microbiota plays a crucial role in rectal adenocarcinoma (READ). Nonetheless, little is known about corresponding changes in gut microbiota–host interactions. This study aimed to identify the structure of the gut microbiota and the characteristics of faecal metabolites in patie...

2025-06-29 | MTBLS12620 | MetaboLights
TranscriptomicsGastric Cancer Subtyping (Australian Patient Cohort)
Genome-wide mRNA expression profiles of 70 primary gastric tumors from the Australian patient cohort. Like many cancers, gastric adenocarcinomas (gastric cancers) show considerable heterogeneity between patients. Thus, there is intense interest in using gene expression profiles to discover subtypes ...
ORGANISM(S): Homo sapiens 
2012-07-04 | E-GEOD-35809 | biostudies-arrayexpress
ProteomicsThe post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell
This research explores the antiproliferative effects of short-chain fatty acid (SCFA) salts (magnesium acetate, sodium propionate, and sodium butyrate) on AGS gastric adenocarcinoma cells. Sodium butyrate (NaB) exhibited the most significant inhibitory impact. The study investigated synergistic inte...
ORGANISM(S): Homo sapiens (Human) 
2024-02-21 | PXD048617 | Pride
Gastric cancer Proteomics Postbiotics Sodium butyrate Dexamethasone Synergy 
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
TranscriptomicsGenetic changes in gastric adenoca tumors
The genetic changes in gastric adenocarcinoma are extremely complex and reliable tumor markers have not yet been identified. There are also remarkable geographical differences in the distribution of this disease. Our aim was to identify the most differentially regulated genes in 20 gastric adenocarc...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-MTAB-1440 | biostudies-arrayexpress
TranscriptomicsAffymetrix 250K StyI SNP array data for gastric and esophageal adenocarcinoma cancer types
Using data from high-density genomic profiling arrays, we describe the profiles of somatic copy-number aberrations (SCNAs) in 486 adenocarcinomas across all three major digestive organs, including 296 gastric and esophageal cancers. This analysis revealed that although patterns of broad, chromosome ...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-36459 | biostudies-arrayexpress
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