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UnknownNegative regulation of HBG1/2 expression through S6K by long noncoding RNA NR_120526.
Not available
S-EPMC10248940 | biostudies-literature
UnknownComparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34+ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin.
Not available
S-EPMC7311455 | biostudies-literature
GenomicsMicro-Capture-C to determine the long-range interaction of HBG1/2 promoter with the locus control region (LCR), a powerful upstream enhancer in -175 A>G mutantant HUDEP-2 cells.
Micro-Capture-C to determine the long-range interaction of HBG1/2 promoter with the locus control region (LCR), a powerful upstream enhancer in -175 A>G mutantant HUDEP-2 cells.
PRJNA951691 | ENA
ProteomicsTemporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by down-regulation of BCL11A is a promising treatment of -hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of -globin gene (HBG1/2) transcription is lacking, as studies to date used perturbations by shRNA or CRISPR/Cas9 gene editi...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD030307 | Pride
Proteomics Data-independent acqusition Protac Mass spectrometry Bcl11a Hemoglobinopathies 
ProteomicsTemporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by down-regulation of BCL11A is a promising treatment of -hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of -globin gene (HBG1/2) transcription is lacking, as studies to date used perturbations by shRNA or CRISPR/Cas9 gene editi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-27 | PXD030301 | Pride
Dtag Protac Bcl11a Degradation 
ProteomicsMulti-omics analysis into the molecular mechanisms underlying the up-regulation of HBG1/2 expression induced by HBB deletion
A multi-omics study examining chromatin accessibility, transcriptome, proteome and phosphorylation patterns in the HBB homozygous knockout of the HUDEP2 cell line (HBB-KO)
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030182 | Pride
Omics-study  hbb  hbg1/2  hif1 pathway  stress erythropoiesis 
GenomicsNFI factors repress fetal hemoglobin in adult erythorid cells [ATAC-seq]
The mechanisms by which the fetal type b-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells is a basic biology question in human development. Reversal of such mechanisms is beneficial for b hemoglobinopathies, such as sickle cell disease (SCD). A CRISPR-Cas9 genetic scre...
ORGANISM(S): Homo sapiens 
2022-03-23 | GSE180855 | GEO
TranscriptomicsNFI factors repress fetal hemoglobin in adult erythorid cells [RNA-seq]
The mechanisms by which the fetal type b-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells is a basic biology question in human development. Reversal of such mechanisms is beneficial for b hemoglobinopathies, such as sickle cell disease (SCD). A CRISPR-Cas9 genetic scre...
ORGANISM(S): Homo sapiens 
2022-03-23 | GSE180869 | GEO
GenomicsNFI factors repress fetal hemoglobin in adult erythorid cells [CUT&RUN]
The mechanisms by which the fetal type b-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells is a basic biology question in human development. Reversal of such mechanisms is beneficial for b hemoglobinopathies, such as sickle cell disease (SCD). A CRISPR-Cas9 genetic scre...
ORGANISM(S): Homo sapiens 
2022-03-23 | GSE180860 | GEO
TranscriptomicsTranscriptome of erythroid cells derived from human CD34+ cells edited at the BCL11A erythroid enahncer or at the HBG1 and HBG2 promoters using CRISPR-Cas9
BCL11A represses gamma globin expression by binding to the gamma globin gene (HBG1 and HBG2) promoters. Genome editing of the BCL11A erythroid enhancer in the intron 2 of BCL11A gene or the BCL11A binding site at the HBG1/2 promoters disrupts this pathway and leads to gamma globin induction. Transcr...
ORGANISM(S): Homo sapiens 
2024-12-10 | GSE264491 | GEO
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