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GenomicsHdac6 regulates Tip60-p400 function in stem cells (sequencing)
The Tip60 (also known as Kat5) lysine acetyltransferase functions broadly as a transcriptional co-activator that acetylates histones. In contrast, Tip60 functions in embryonic stem cells (ESCs) both to silence genes that promote differentiation and to activate genes required for proliferation. The m...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-42209 | biostudies-arrayexpress
TranscriptomicsHDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells
Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC ...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-27896 | biostudies-arrayexpress
ProteomicsProteomic profiling of CSE- and HDAC6-knockout EA.hy926 cells
Hydrogen sulfide (H₂S) is an endogenous gasotransmitter implicated in the regulation of protein function. This study investigates whether H₂S-derived sulfur species can engage the catalytic Zn²⁺ center of histone deacetylase 6 (HDAC6) and influence HDAC6-dependent deacetylation. Molecular dynamics s...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD059587 | Pride
Hydrogen sulfide  hdac6  endothelial cells  hplc-ms. 
ProteomicsMetabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
ORGANISM(S): Mus Musculus 
PXD055797 |
ProteomicsProteomics study of HDAC6 silenced cells
The proteomic analysis here introduced was set up and performed to figure out global perturbations of the proteome of a breast cancer human cell line in the presence/absence of HDAC6 silencing.
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD054378 | Pride
Shot-gun Hdac6 Mass spectrometry 
ProteomicsAcetylomic profiling of CSE- and HDAC6-knockout EA.hy926 cells
Hydrogen sulfide (H₂S) is an endogenous gasotransmitter implicated in the regulation of protein function. This study investigates whether H₂S-derived sulfur species can engage the catalytic Zn²⁺ center of histone deacetylase 6 (HDAC6) and influence HDAC6-dependent deacetylation. Molecular dynamics s...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD059553 | Pride
Hydrogen sulfide  hdac6  endothelial cells  hplc-ms. 
TranscriptomicsGene expression profile changes in HDAC6 knockdown HT1080 cells cells after TLR3 stimulation
TLR3 stimulation by extracellular dsRNA (e.g. polyIC) induces expression of numerous genes. The knockdown of HDAC6 prior to TLR3 stimulation leads to an ablation of expression of IRF-3-dependent genes. Total RNA extracted from HT1080 cells expressing control-shRNA or HDAC6-shRNA, after 6 h of treatm...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-43218 | biostudies-arrayexpress
ProteomicsHDAC6 deacetylates TRIM56 to negatively regulate cGAS-mediated type I interferon response
Histone deacetylase 6 (HDAC6), a member of the class IIB HDAC family, has distinct biological functions through primarily deacetylating cytoplasmic non-histone proteins. However, its regulatory role in response to DNA virus infection remains elusive. Herein, we find that HDAC6 is a negative regulato...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-21 | PXD046808 | Pride
Hsv-1 Trim56 Cgas Hdac6 Ifn-i Deacetylation 
GenomicsHDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ChIP-Seq)
HDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ChIP-Seq)
PRJNA1142561 | ENA
GenomicsHDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ATAC-Seq)
HDAC6 Inhibition Disrupts HDAC6-P300 Interaction Reshaping the Cancer Chromatin Landscape (ATAC-Seq)
PRJNA1142562 | ENA
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