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TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase 6 exerts dichotomous effects on the Hedgehog signaling cascade
Murine embryo fibrablosts from stably transfected with Sonic Hedgehog were treated with siRNA and their transcription profiles captured.
ORGANISM(S): Mus_musculus 
2015-01-26 | E-MTAB-2440 | biostudies-arrayexpress
TranscriptomicsExpression data from colon fibroblasts treated with Sonic hedgehog homolog (SHH)
Canonical Hedgehog (Hh) signaling regulates the expression of genes that are critical to the patterning and development of a variety of organ systems. In adult, both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tu...
ORGANISM(S): Homo sapiens 
2011-05-17 | E-GEOD-29316 | biostudies-arrayexpress
ProteomicsTargeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Illustrative of these are the many screens that have been conducted to find inhibitors for the Hedgehog (Hh) signaling pathway – a major developmental pathway with many implications in health and disease ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036539 | Pride
Hedgehog pathway Protac Protein degradation 
GenomicsA new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation
Hepatocellular adenomas (HCA) are benign liver tumors divided in molecular subtypes characterized by mutations inactivating HNF1A, activating β-catenin or the IL-6/JAK/STAT inflammatory pathway. Molecular analyses of 533 HCA developed in 411 patients identified a new tumor subgroup with Sonic Hedgeh...
EGAS00001002091 | EGA
ProteomicsPhosphoproteomics of induced and inhibited early Hh signaling in human medulloblastoma cells
Aberrant sonic hedeghog signaling is implicated in the development of various cancer entities such as medulloblastoma. The canonical signaling cascade has been studied for years. Activation of GLI transcription factors was revealed as the driving force upon pathway activation. Phosphorylation by Pro...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013408 | Pride
Phosphoproteomics Medulloblastoma Daoy cells Hedgehog signaling Phosphorylation 
ModelsSivakumar2011 - Hedgehog Signaling Pathway
Sivakumar2011 - Hedgehog Signaling Pathway This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the ident...
2024-09-02 | BIOMD0000000395 | BioModels
TranscriptomicsGene expression in mice with conditional over-activation of hedgehog signaling in the ovary
The objective of the study was to determine the cause of anovulation in transgenic mice with conditional over-activation of the hedgehog signaling pathway in the ovary. In Amhr2(cre/+)-SmoM2 transgenic mice, a constitutively active version of the hedgehog signal transducer, smoothened (SMO), known ...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-35123 | biostudies-arrayexpress
ProteomicsThe Drosophila Epidermal growth factor receptor pathway regulates Hedgehog signalling and cytoneme behaviour.
During Drosophila epithelial development, dynamic signalling filopodia (cytonemes) establish direct contacts between distant cells to facilitate the formation of the Hedgehog signalling gradient. However, not much is known about how cytonemes are regulated. In this study, we show that cytoneme dynam...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-05-06 | PXD040793 | Pride
Ihog Development. Hedgehog signalling Egfr Cytonemes 
ProteomicsPP2A Phosphatase Regulatory Subunit PPP2R3C is a New Positive Regulator of the Hedgehog Signaling Pathway
Cellular signaling pathways rely on posttranslational modifications (PTMs) to finely regulate protein functions, particularly transcription factors. The Hedgehog (Hh) signaling cascade, crucial for embryonic development and tissue homeostasis, is susceptible to aberrations that lead to developmental...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-10 | PXD054802 | Pride
Ppp2r3c  pp2a  phosphatases  hedgehog signaling  gli  phosphorylation  
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