Heart failure with reduced ejection fraction (HFrEF) remains a major therapeutic challenge. Bcl2-associated transcription factor 1 (Bclaf1) is implicated in RNA splicing and cardiac disease, but its role in HFrEF pathogenesis is unknown. Here, we demonstrate that Bclaf1 expression is elevated in hum...
Heart failure (HF) diagnosis is complicated by varied pathophysiology, nonspecific symptoms and underlying comorbidities. This patient heterogeneity makes accurate treatment challenging and, as a result, can lead to worse clinical outcomes and increased healthcare cost. Measuring the plasma concentr...
