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TranscriptomicsSingle-cell analysis of T-cells from mouse neonate thymuses in a wild type control and a placental specific isoform of Igf2 knock-down (igf2-P0)
Fetal growth restriction (FGR) causes a wide variety of developmental defects in the neonate which can lead to heart disease, diabetes, anxiety and other disorders later in life. The effect of FGR on the immune system, however, is poorly understood. Immune cells throughout development are identified...
ORGANISM(S): Mus musculus 
2018-11-06 | E-MTAB-6945 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profiling of the Igf2 pathway dependency of Trp53 developmental and tumour phenotypes in mice
We tested whether loss of p53 function leads to insulin-like growth factor 2 (IGF2) pathway dependency in vivo in genetically defined mouse models. Unexpectedly we found lethality, due to post-natal lung haemorrhage, occurred in Igf2 paternal null allele female mice (Igf2-p) but only if derived from...
ORGANISM(S): Mus musculus 
2012-06-01 | E-MTAB-1001 | biostudies-arrayexpress
TranscriptomicsmicroRNA Profiling in Wilms Tumors and Kidney Tissues
The IGF2-intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. The expression levels of microRNAs were profiled in 20 human Wilms tumor samples (WT), 3 human normal adult kidney samples (AK) and 5 human fetal kidney samples (FK) using a Luminex bea...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50505 | biostudies-arrayexpress
ProteomicsSynaptosome proteome IGF2 enhancer knockout mice
We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic ...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-31 | PXD012786 | Pride
Dopamine Schizophrenia Striatum Synaptosome Igf2 
TranscriptomicsMicroRNA expression profiling of Igf2-p and H19-m mutant mouse embryos
Changes in microRNA expression in Igf2-p and H19-m mouse embryos (E9.5) were determined in order to assess whether perturbation of miR-483* and miR-675 in Igf2-p and H19-m mutants was likely to have contributed to a modification of tumour phenotype. The Igf2 gene contains miR-483* but the targeted d...
ORGANISM(S): Mus musculus 
2011-12-01 | E-MTAB-873 | biostudies-arrayexpress
TranscriptomicsIGF2 shRNA knockdown in the colorectal cancer (CRC) cell line SW480
In order to identify gene expression changes associated with the deregulated of IGF2, Doxycylin inducible empty vector and IGF2 shRNA permanent cell lines were generated by lentivral transduction in the colorectal cancer (CRC) cell line SW480 and selected with puromycin. For microarray analysis, bot...
ORGANISM(S): Homo sapiens 
2016-04-30 | E-MTAB-3786 | biostudies-arrayexpress
ProteomicsUrinary Glycosylated IGF2 peptides in association with CKD
Chronic kidney disease (CKD) is prevalent in 10% of world’s adult population, with Estimated Glomerular filtration rate (eGFR) and albuminuria employed in diagnosis. Role of protein glycosylation in causal mechanisms of CKD progression is largely unknown. Aim of this study was to identify urinary O-...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039829 | Pride
Ckd  egfr  post translational modifications  ptms  glycosylation  urine  peptidomics  glyco-peptide  igf2 
TranscriptomicsGene expression profiles of dental follicle cells after 7 days of differentiation in vitro with BMP2, IGF2 and dexamethasone
We analysed gene expression profiles in dental follicle cells after 7 days of osteogenic differentiation with different inducers. Total RNAs were isolated from dental follicle cells after 7 days of differentiation with dexamethasone, BMP2, IGF2 and for control with standard cell culture medium
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-20963 | biostudies-arrayexpress
ProteomicsSecretome and phosphoproteome analysis of THP-1 and KOPN-8 cells treated with Insulin-like growth factor 2.
We describe the secretome and phosphoproteome of human leukemia cell lines, THP-1 and KOPN-8, treated with Insulin-like growth factor 2 (IGF2) using data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD049016 | Pride
Leukemia Secretome Extracellular Data-independent acquisition Phosphoproteome Igf2 
GenomicsIGF2 deficiency induces sarcopenia and muscle functional decline
IGF2 deficiency induces sarcopenia and muscle functional decline
PRJNA1185172 | ENA
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