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MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
MetabolomicsJiawei Shoutai Pill Promotes Embryo Implantation via PPAR Signaling and Endometrial Microbiota Remodeling: An Integrative Multi-Omics Study
Background: Recurrent implantation failure (RIF) remains a major barrier to successful assisted reproductive technology, given the lack of effective, mechanism-informed interventions to enhance endometrial receptivity. Jiawei Shoutai Wan (pills) (JWSTW), a modified formulation of the classic Shoutai...
2026-03-31 | MTBLS14199 | MetaboLights
ProteomicsConformational dynamics of the activated GLP-1 receptor-Gs complex revealed by cross-linking mass spectrometry and integrative modeling
Despite revolutionary advancements in GPCR structural biology, our understanding of the complexity of GPCR activation and signaling would not be complete without complementary information on the conformational dynamics. Yet it is particularly challenging to study the dynamics of GPCR complexes with ...
ORGANISM(S): Homo Sapiens 
2023-01-08 | PXD039315 |
ProteomicsA3G-Vif-CBFB-CRL5 Cross-Linking with DSSO
Here we use an optimization cross-linking mass spectrometry (XL-MS) pipeline for the structural characterization of a dynamic HIV-host protein complex. Using DSSO-based XL-MS analysis, residue-protein proximity restraints based on functional genetics, and integrative modeling, we define the structu...
ORGANISM(S): Homo sapiens (Human) Human immunodeficiency virus 
2021-11-03 | PXD025391 | Pride
Xl-ms Dsso Apobec3g Hiv vif Integrative modeling 
TranscriptomicsIntegrative Molecular Concepts Modeling of Prostate Cancer Progression
Using laser capture microdissection to isolate over 100 specific cell populations, we report the profiling of prostate cancer progression from benign epithelium to metastatic disease. By analyzing these expression signatures in the context of over 15,000 â??molecular conceptsâ??, or sets of biologic...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-6099 | biostudies-arrayexpress
UnknownIntegrative structure modeling with the Integrative Modeling Platform.
Not available
S-EPMC5734277 | biostudies-literature
TranscriptomicsIntegrative modeling defines the Nova splicing-regulatory network and its combinatorial controls: Exon array data
The control of RNA alternative splicing is critical for generating biological diversity. Despite emerging genome-wide technologies to study RNA complexity, reliable and comprehensive RNA-regulatory networks have not been defined. Here we used Bayesian networks to probabilistically model diverse data...
ORGANISM(S): Mus musculus 
2010-08-04 | E-GEOD-22115 | biostudies-arrayexpress
ProteomicsElucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
PTEN (Phosphatase and TENsin homolog deleted on chromosome ten) is a major tumor suppressor gene that is frequently mutated or lost under cancerous conditions. PTEN is a dual-specificity phosphatase that negatively regulates the PI3K/AKT/mTOR signaling pathway at the plasma membrane (PM). Its functi...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD059974 | Pride
Molecular dynamics Molecular modeling Molecular biology Conformational change Rasp stability prediction Crosslinking mass spectrometry (xl-ms) Alphamissense Clinical mutation Integrative structural modeling Phosphatase and tensin homolog (pten) 
ProteomicsIMProv: A Resource for Crosslink-Driven Structure Modeling that Accommodates Protein Dynamics
Crosslinking and hydrogren-deuterium exchange data of Polycomb Repressive Complex 2 used for integrative modelling.
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD022861 | Pride
Crosslinking mass spectrometry Software Integrative modelling 
UnknownDisentangling constraints using viability evolution principles in integrative modeling of macromolecular assemblies.
Not available
S-EPMC5427971 | biostudies-literature
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