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ProteomicsThe spliceosome factor USP39 promotes hepatocellular carcinoma malignancy through regulating mRNA splicing
Abnormal alternative splicing (AS) caused by alterations to splicing factors contributes to tumor progression. Nonetheless, the relevant targets and mechanisms remain elusive in hepatocellular carcinoma (HCC). Here, we reported that overexpression of Ubiquitin-specific protease 39 (USP39), a spliceo...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035928 | Pride
Alternative splicing  kank2  srsf6  hnrnpc  constitutive splicing 
ProteomicsThe composition of reticular adhesions in RPMI-7951 and MDA-MB-435S melanoma cell lines and its comparison with the reticular adhesion composition following talin2 or KANK2 knockdown
Integrins bind extracellular matrix proteins and, when clustered, form integrin adhesion complexes (IACs) that connect to and regulate the cytoskeleton, shaping normal and tumour cell behaviour. In addition to well-known nascent adhesions, focal adhesions (FAs), fibrillar adhesions (FBs), and hemide...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071922 | Pride
Reticular adhesions Kank2 Matrisome Adhesome Melanoma Rpmi-7951 cells Integrin alphavbeta5 Talin2 Mda-mb-435s cells 
UnknownNephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
Not available
S-EPMC8368038 | biostudies-literature
UnknownPan-Cancer Analysis of KANK2: Clinical and Molecular Insights into Tumor Progression and Therapeutic Implications.
Not available
S-EPMC11786046 | biostudies-literature
UnknownTalin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
Not available
S-EPMC10353188 | biostudies-literature
UnknownKANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration.
Not available
S-EPMC7063070 | biostudies-literature
UnknownStructural basis for the recognition of kinesin family member 21A (KIF21A) by the ankyrin domains of KANK1 and KANK2 proteins.
Not available
S-EPMC5767861 | biostudies-literature
UnknownCross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy.
Not available
S-EPMC10622416 | biostudies-literature
UnknownKANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
Not available
S-EPMC4497755 | biostudies-literature
UnknownPERM1 regulates energy metabolism in the heart via ERRα/PGC-1α axis.
Not available
S-EPMC9676655 | biostudies-literature
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