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TranscriptomicstRNA fragment profiling in CLP1 mutant (kinase-dead) mice
Loss of CLP1 activity results in the accumulation of novel sets of small RNA fragments derived from aberrant processing of tyrosine pre-tRNA. Such tRNA fragments sensitize cells to oxidative stress-induced p53 activation and p53-dependent cell death. 2 samples, Wt and Clp1(k/k), no replicates
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-39275 | biostudies-arrayexpress
GenomicsATAC seq in murine BCR-ABL(p185)-positive pre/pro B-cells expressing wildtype CDK6 or a kinase-dead mutant (CDK6 K43M)
ATAC seq in murine BCR-ABL(p185)-positive pre/pro B-cells expressing wildtype CDK6 or a kinase-dead mutant (CDK6 K43M)
PRJNA1106899 | ENA
GenomicsATAC seq in murine BCR-ABL(p185)-positive pre/pro B-cells expressing wildtype CDK6 or a kinase-dead mutant (CDK6 K43M)
The aim of this experiment was to study the chromatin accessibility in BCR-ABL(p185)-positive pre/pro B-cells expressing wildtype CDK6 or a kinase-dead mutant (CDK6 K43M)
ORGANISM(S): Mus musculus 
2025-02-26 | GSE266393 | GEO
TranscriptomicsGenome-wide analysis of SIK2 regulated genes and pathways
Identification of SIK2 regulated genes and pathways after SIK2 knock-down and overexpression of a wild-type and kinase-dead SIK2. The hypothesis is that SIK2 regulated gene expression via CREB1 Total RNAs were obtained after SIK2 gene was knocked down with siRNA and after a wild-type SIK2 or a kinas...
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-45711 | biostudies-arrayexpress
UnknownGenome wide transcription profiling of the effects of overexpression of Spc1 and its kinase dead mutant in Schizosaccharomyces pombe.
Not available
S-EPMC4664770 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from wild type and IRAK-4 kinase dead animals stimulated with IL-1b for different durations to identify IRAK-4 kinase-dependent IL-1b response genes.
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll-like receptors. Though regarded as the first kinase in the signaling cascade, the role of IRAK-4 kinase activity versus its scaffold function is still controversial. In order to investigate the role ...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6789 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by LKB1 expression in human lung adenocarcinoma cell lines
LKB1 is a tumor suppressor lost in approximately 30% of lung adenocarcinomas. It is a serine-threonine kinase involved in regulating metabolism, proliferation, and cell polarity. We have characterized its association with mRNA expression profiles in resected tumors and in cell lines, but little is k...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51266 | biostudies-arrayexpress
UnknownThe neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo.
Not available
S-EPMC3140014 | biostudies-literature
ProteomicsProximity labelling identification of ULK1 wild-type (WT) and ULK1-K46I (kinase dead) interactors upon mitochondria tethering in U2OS WT cells
This project involved generating three stable cell lines using a Flp-In system, each containing specific integrated constructs: "FKBPx2-myc-APEX2-ULK1", "FKBPx2-myc-APEX2-ULK1-K46I" (kinase-dead mutant), and "FKBPx2-myc-APEX2" (control). All cell lines additionally express an outer mitochondrial mem...
ORGANISM(S): Homo sapiens (Human) 
2026-04-24 | PXD068381 | Pride
Mitophagy Autophagy Ulk1-k46i Ulk1 Proximity labeling Apex2 
TranscriptomicsSuppressio​n of MicroRNA-9 by Mutant EGFR Signaling Induces FOXP1 to Enhance Glioblasto​ma Tumorigeni​city
The EGF-receptor (EGFR) is amplified and mutated in glioblastoma (GBM) where its common mutation, (∆EGFR, also called EGFRvIII) has a variety of activities that promote growth and inhibit death, thereby conferring a strong tumor-enhancing effect. This range of activities suggested to us that ∆EGFR m...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-53504 | biostudies-arrayexpress
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