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TranscriptomicsTranscription profiling of diaphragm muscles from alpha2-laminin (merosin)-deficient dy/dy dystrophic mice and wild type mice to study differential gene expression.
Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Experiment Overall Design: 4 normal samples; 4 dystrophic samples; Each sample consists of muscle pooled from 3 mice, thus a total of 12 normal and 12 dystrophic mice were studied
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3252 | biostudies-arrayexpress
ProteomicsProteomic-based research strategy identified laminin subunit alpha 2 as a potential urinary-specific biomarker for the medullary sponge kidney disease
Medullary sponge kidney (MSK) disease, a rare kidney malformation featuring recurrent renal stones and nephrocalcinosis, continues to be diagnosed using expensive and time-consuming clinical/instrumental tests (mainly urography). Currently, no molecular diagnostic biomarkers are available. To identi...
ORGANISM(S): Homo sapiens (Human) 
2021-05-24 | PXD025744 | Pride
Biomarker  laminin subunit alpha 2  msk  proteomic 
TranscriptomicsTranscription profiling of mouse laminin alpha 2 chain deficient animals vs wild type
Mutations in the gene encoding laminin a2 chain cause congenital muscular dystrophy, MDC1A. In skeletal muscle, laminin a2 chain binds at least two receptor complexes; the dystrophin-glycoprotein complex and integrin a7b1. To gain insight into the molecular mechanisms underlying this disorder, we pe...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-12049 | biostudies-arrayexpress
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080848 | MassIVE
TranscriptomicsTranscription profiling of mouse C2C12 myoblast induced with tetracycline to enhance integrin alpha7 expression
Analysis of C2C12 myoblast induced with tetracycline to enhance integrin alpha7 expression. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this s...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8312 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse skeletal muscle of integrin alpha7 overexpressing animals vs controlls
Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dyst...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8313 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile of mouse Lewis lung carcinoma LLC1 cell line cultivated in 2-dimensional or 3-dimensional cell culture enriched with laminin rich extracellular matrix proteins
The extracellular matrix (ECM), as one of the key components of tumor microenvironment has a high impact on cancer development and highly influences tumor cell features. ECM contribute not only structural support to growing tumor cells, but also affect other cellular functions such as cell different...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-75862 | biostudies-arrayexpress
TranscriptomicsExpression data from laminin alpha 2 chain deficient mice vs wild type
Mutations in the gene encoding laminin a2 chain cause congenital muscular dystrophy, MDC1A. In skeletal muscle, laminin a2 chain binds at least two receptor complexes; the dystrophin-glycoprotein complex and integrin a7b1. To gain insight into the molecular mechanisms underlying this disorder, we pe...
ORGANISM(S): Mus musculus 
2008-07-10 | GSE12049 | GEO
ProteomicsGBM cell line secretome analysis
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The purpose of the present study was to identify GBM cell-selective secreted proteins by analyzing conditioned media (CM) from GBM, breast, and colon cancer cell lines using sequential window acquisition of all theoretical s...
ORGANISM(S): Homo Sapiens (human) 
2020-09-19 | PXD016898 | JPOST Repository
TranscriptomicsAbnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice
Laminins are major constituents of basement membranes and are essential for tissue homeostasis. Laminin-511 is highly expressed in the intestine and its absence causes severe malformation of the intestine and embryonic lethality. To understand the mechanistic role of laminin-511 in tissue homeostasi...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-31334 | biostudies-arrayexpress
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