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ProteomicsStudy on the changes of extracellular matrix morphology and components in COPD animal model by using lung decellularized scaffold
Airway remodeling is a critical pathological process that influences the progression of chronic obstructive pulmonary disease（COPD）. To better study small airway remodeling in COPD, we employed advanced techniques such as decellularized scaffolds and proteomics to analyze compositional changes in th...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058944 | Pride
Copd（chronic obstructive pulmonary disease）  ecm（extracellular matrix）  lung decellularized scaffolds  airway remodeling  proteomics 
ProteomicsMatrisome properties of scaffolds direct fibroblasts in idiopathic pulmonary fibrosis
In this study we have focused on the biomechanical properties of scaffolds (decellularized lung tissue) derived from healthy individuals and IPF patients. The longitudinal cellular response of scaffold repopulation with healthy fibroblasts has been quantified using SILAC-MS. Increased scaffold densi...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD012322 | Pride
Ipf Silac-ms Scaffold Repopulation Lung tissue 
GenomicsWhole transcriptome analysis of control human fibroblasts, TGFβ-induced human fibroblasts, and fibroblasts co-cultured with normal lung decellularized scaffolds and fibroblasts co-cultured with bleomycin-induced lung decellularized scaffolds.
Whole transcriptome analysis of control human fibroblasts, TGFβ-induced human fibroblasts, and fibroblasts co-cultured with normal lung decellularized scaffolds and fibroblasts co-cultured with bleomycin-induced lung decellularized scaffolds.
PRJNA1152263 | ENA
TranscriptomicsmRNA-seq of mouse lung vascular endothelial cells and mouse liver sinusoidal endothelial cells before and after their partial reprogramming into progenitor-like cells and recellularization of decellularized mouse lung scaffolds
In this study we developed highly proliferative and lineage restricted lung endothelial derived progenitor-like cells using the transient expression of Yamanaka factors via doxycycline inducible system combined with LIF-supplemented media. We investigate the potential of these induced progenitor-lik...
ORGANISM(S): Mus musculus 
2020-06-23 | E-MTAB-8394 | biostudies-arrayexpress
GenomicsMapping of matrsisome production by alveolar epithelial cells cultured in decellularized human lung scaffolds
Mapping of matrsisome production by alveolar epithelial cells cultured in decellularized human lung scaffolds
PRJNA790837 | ENA
TranscriptomicsWhole transcriptome analysis of control human fibroblasts, TGFβ-induced human fibroblasts, and fibroblasts co-cultured with normal lung decellularized scaffolds and fibroblasts co-cultured with bleomycin-induced lung decellularized scaffolds.
Fibrosis refers to the abnormal proliferation and excessive accumulation of fibrous tissue in an organ or tissue, typically caused by chronic injury or inflammation. Fibroblasts play a crucial role in the initiation and progression of fibrosis, with their excessive activation and overproduction of E...
ORGANISM(S): Homo sapiens 
2025-08-20 | GSE275625 | GEO
OtherQuantification of Extracellular Matrix Proteins from a Rat Lung Scaffold to Provide a Molecular Readout for Tissue Engineering.
Data from ProteomeXchange, PXD ID: PXD001213. File: 20121108_Native_Frac3_Lung01_Run03.mzml. Published as part of . From the Abstract: {{i}} ... To support organ engineering efforts, we developed a targeted proteomics method to extract and quantify extracellular matrix components from tissues. Our ...
ORGANISM(S): Rat 
GPM32310006954 | GPMDB
Resource Reanalysis 
TranscriptomicsMapping of matrsisome production by alveolar epithelial cells cultured in decellularized human lung scaffolds
The alveolar epithelial cells are known producers of basement membrane components of the ECM, we hypothesize that they may also contribute substantially to remodeling of interstitial ECM in the alveolar compartment in chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and idi...
ORGANISM(S): Homo sapiens 
2022-10-31 | GSE191279 | GEO
GenomicsmRNA-seq of mouse lung vascular endothelial cells and mouse liver sinusoidal endothelial cells before and after their partial reprogramming into progenitor-like cells and recellularization of decellularized mouse lung scaffolds
mRNA-seq of mouse lung vascular endothelial cells and mouse liver sinusoidal endothelial cells before and after their partial reprogramming into progenitor-like cells and recellularization of decellularized mouse lung scaffolds
PRJEB34800 | ENA
TranscriptomicsAdvancing Lung Tissue Engineering Through the Discovery of Factors that Control Alveolar Epithelial Cell Fate (snRNA-seq from recellularized scaffolds)
The objective of this study was to evaluate primary, human AT2 cells following seeding into decellularized lung scaffolds.
ORGANISM(S): Homo sapiens 
2025-12-18 | GSE306714 | GEO
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