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MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
ProteomicsProfiling the LAM family of contact-site tethers provides mechanistic insights into their regulation and function
Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051014 | Pride
Membrane contact sites  endoplasmic reticulum  lam protein family  proximity labelling  abolish 
ProteomicsProfiling the LAM family of contact-site tethers provides mechanistic insights into their regulation and function
Membrane contact sites are molecular bridges between organelles that are sustained by tethering proteins and enable organelle communication. The endoplasmic reticulum (ER) membrane harbors many distinct families of tether proteins that enable the formation of contacts with all other organelles. One ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-03-10 | PXD051047 | Pride
Membrane contact sites  endoplasmic reticulum  lam protein family  proximity labelling  abolish 
TranscriptomicsNickel-induced contact dermatitis induce changes in human skin transcriptome over 96 hours
We aimed to characterize transcriptomic changes over time (baseline, 2 hours, 48 hours and 96 hours) after nickel-induced contact dermatitis in 6 human probands. As a contrast, 7 patients with SLS-induced irritant contact dermatitis were included. Therefore, the patch tests were applied onto the bac...
ORGANISM(S): Homo sapiens 
2020-05-01 | E-MTAB-8945 | biostudies-arrayexpress
ProteomicsContact-ID, a new tool for profiling organelle-membrane contact sites, reveals regulatory proteins of mitochondrial-associated membrane formation
The mitochondria-associated membrane (MAM) has emerged as a cellular signaling hub regulating various cellular processes. However, its molecular components remain unclear owing to lack of reliable methods to purify the intact MAM proteome in a physiological context. Here, we introduce Contact-ID, a ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084362 | MassIVE
ProteomicsHuman VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs
Membrane contact sites (MCS) are intracellular regions where two organelles come closer to exchange information and material. The majority of the endoplasmic reticulum (ER) MCS are attributed to the ER-localized tether proteins VAPA, VAPB, and MOSPD2. These recruit other proteins to the ER by intera...
ORGANISM(S): Homo sapiens (Human) 
2023-06-29 | PXD043399 | Pride
Emery-dreifuss muscular dystrophy  ffat  ffnt  mospd1  mospd2  mospd3  vapa  vapb  endoplasmic reticulum  membrane contact sites 
TranscriptomicsExpression data from human healthy EPCs/CACs
Systemic lupus erythematosus (SLE) is characterized by increased vascular risk due to premature atherosclerosis independent of traditional risk factors. We previously proposed that interferon-? plays a crucial role in premature vascular damage in SLE. IFN-? alters the balance between endothelial cel...
ORGANISM(S): Homo sapiens 
2011-04-13 | E-GEOD-26949 | biostudies-arrayexpress
TranscriptomicsExpression data from human lupus EPCs/CACs
Systemic lupus erythematosus (SLE) is characterized by increased vascular risk due to premature atherosclerosis independent of traditional risk factors. We previously proposed that interferon-α plays a crucial role in premature vascular damage in SLE. IFN-α alters the balance between endothelial cel...
ORGANISM(S): Homo sapiens 
2011-04-13 | E-GEOD-26950 | biostudies-arrayexpress
ProteomicsAPEX2 proximity labeling of PI(3)P dependent ER and early endosome membrane contact tether proteins
To understand the nature of ER and early endosome membrane contact site, we capitalized the MTM1 knock out (KO) HeLa cells that do not dissociate the ER and early endosome membrane contact upon nutrient starvation. By using the Doxycyclin inducible APEX2 fused Rab5A (early endosome marker) expressin...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD033846 | Pride
Hela Apex2 Lc-ms Mtm1 Early endosome Er Membrane contact 
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