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ProteomicsMHC class I ligandome of cells treated with palladium
MHC class I ligandome analysis of mouse dendritic cells treated with palladium
ORGANISM(S): Mus Musculus (mouse) 
2021-12-16 | PXD028795 | JPOST Repository
ProteomicsQuantitative Measurement of the Requirement of Diverse Protein Degradation Pathways in MHC Class I Peptide Presentation
The adaptive immune system distinguishes self from non-self by surveying peptides generated from degradation of intracellular proteins that are loaded onto MHC Class I molecules for display on the cell surface. While early studies reported that the bulk of cell surface MHC Class I complexes require ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-15 | MSV000091285 | MassIVE
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-19 | MSV000084980 | MassIVE
ProteomicsProteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas
The peptides repertoire presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules, referred to as the MHC I-associated peptidome (MIP), regulates all critical events that occur during the lifetime of CD8+ T cells. The MIP presented by thymic antigen presenting cells (APCs...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031966 | Pride
Pancreas Lc-ms/ ms Nod mouse Mhc class i-associated peptidome T1d Cd8+ t-cell. Thymus 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-19 | PXD008733 | Pride
Tissue Mass spectrometry Mhc Immunopeptidome Map 
ProteomicsIsolation of mouse and human MHC class I- and II-associated peptides for the analysis of immunopeptidomes by mass spectrometry
Immunopeptidomics is an emerging field that fuels and guides the development of vaccines and immunotherapies. More specifically, it refers to the science of investigating the composition of peptides presented by major histocompatibility complex (MHC) class I and class II molecules using mass spectro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-07 | PXD028633 | Pride
Mhc class i associated peptides Mass spectrometry Human Immunopeptidome Mhc class ii associated peptides Mouse 
ProteomicsNative mass spectrometry of peptide-free and partially loaded MHC class I molecules
A disulfide-stabilized MHC class I molecule (HLA-A*02:01(Y84C/A139C), short dsA2) was characterized by native mass spectrometry. dsA2 was shown to be structurally intact in absence of any peptide whereas its wild type form was not. Furthermore, it was observed that the mutation did not disrupt the b...
ORGANISM(S): Homo sapiens (Human) 
2022-05-11 | PXD016708 | Pride
Peptide-binding Hla-a Native ms Human Mhc class i 
ProteomicsEvidence of focusing the MHC class I immunopeptidome by tapasin
Investigation of the repertoire of peptide ligands of highly similar Major Histocompatibility complex (MHC) class I allomorphs differing in tapasin dependence; HLA-B*44:02 (tapasin dependent), HLA-B*44:05 (tapasin independent) and HLA-B*44:05 W147A mutant (tapasin dependent).
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD054743 | Pride
Hla Tapasin Immunopeptidomics 
GenomicsAcrocephalus schoenobaenus MHC class I
Acrocephalus schoenobaenus MHC class I ultra-deep sequencing genotyping
PRJEB11775 | ENA
ProteomicsMHC class I loaded ligands from breast cancer cell lines: A potential HLA-I-typed antigen collection
We sought to build a catalog of epitopes presented by breast cancers using a renewable resource of well-characterized breast cancer cell lines. Starting from 70 breast cancer cell lines, we measured MHC class I abundance and used pre-existing RNAseq data to identify either HLA-A*02 or MHC class I-po...
ORGANISM(S): Homo sapiens (Human) 
2018-01-16 | PXD006406 | Pride
Immune system Mass spectrometry Human Mhc class 1 ligands Hla typing Peptide sequencing Breast cancer Cell lines Immunoprecipitation Rna-seq 
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