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ProteomicsMS for RNA binding preteins in tapasin 3'UTR
Using affinity purification for the detection of RNA-binding proteins in tapasin 3'UTR
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045056 | Pride
Tapasin 3'utr 
ProteomicsEvidence of focusing the MHC class I immunopeptidome by tapasin
Investigation of the repertoire of peptide ligands of highly similar Major Histocompatibility complex (MHC) class I allomorphs differing in tapasin dependence; HLA-B*44:02 (tapasin dependent), HLA-B*44:05 (tapasin independent) and HLA-B*44:05 W147A mutant (tapasin dependent).
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD054743 | Pride
Hla Tapasin Immunopeptidomics 
ProteomicsMass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing
The extreme polymorphisms of human leukocyte antigen (HLA) class I proteins result in structural variations in their peptide binding sites to achieve diversity in antigen presentation. External factors could independently constrict or alter HLA class I peptide repertoires. Such effects of the assemb...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD046825 | Pride
Hla-b*44:02 Hla-b*44:05 Tapasin Peptide binding affinity Tryptophan Peptide loading complex Hla class i Immunopeptidome Half-life Mhc class i 
GenomicsDeep mutational scan of tapasin-TM, a variant of the MHC class 1 chaperone tapasin
Deep mutational scan of tapasin-TM, a variant of the MHC class 1 chaperone tapasin
PRJNA1371766 | ENA
GenomicsmicroRNAs binding with 3'UTR of tapasin
microRNAs binding with 3'UTR of tapasin
PRJNA1004588 | ENA
ProteomicsTapasin assembly surveillance by the RNF185/MBRL ubiquitin ligase complex regulates MHC-I antigen presentation
Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the presentation of antigenic peptides on Major Histocompatibility Complex class I (MHC-I) at the cell surface. The loading of these peptides onto MHC-I depends on t...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-09-17 | PXD048728 | Pride
Rnf185 mbrl tapasin 
OtherDeep mutational scan of tapasin-TM, a variant of the MHC class 1 chaperone tapasin
Tapasin is a member of the peptide loading complex which is responsible for stabilizing empty HLA molecules and facilitating the loading of antigenic peptides. Many neuroblastoma cell lines contain low baseline levels of HLA due to defects in antigen processing and presentation machinery. Supplement...
ORGANISM(S): Homo sapiens 
2026-01-26 | GSE311856 | GEO
GenomicsA deep mutational scan of the MHC class I-specific chaperone tapasin
A deep mutational scan of the MHC class I-specific chaperone tapasin
PRJNA668133 | ENA
UnknownProductive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.
Not available
S-EPMC3249531 | biostudies-literature
GenomicsmicroRNAs binding with 3'UTR of tapasin
Background Dysregulation of major histocompatibility complex (MHC) class I antigen processing and presentation machinery (APM) components in the tumor as one main molecular mechanism of immune escape leading to deactivation of T cell immune surveillance could be due to post-transcriptional regulatio...
ORGANISM(S): Homo sapiens 
2024-09-15 | GSE240665 | GEO
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