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ProteomicsChemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics
Loss-of-function mutations in CDKL5 kinase causes severe neurodevelopmental delay and early-onset seizures. Identification of CDKL5 substrates is key to understanding its function. Using chemical genetics, we found that CDKL5 phosphorylates three microtubule-associated proteins: MAP1S, EB2 and ARHGE...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-18 | PXD010511 | Pride
Chemical genetics/ cdkl5/ map1s/ eb2/ microtubule dynamics 
ProteomicsAutophagy lipidation machinery regulates microtubule dynamics to maintain axonal homeostasis
Axon integrity is crucial for neuronal function. To maintain axonal homeostasis neurons have evolved a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Although abnormal MT-based trafficking highlights the pat...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-25 | PXD011279 | Pride
Microtubule dynamics Neuron Autophagy Lc3 Axonal homoeostasis 
GenomicsHAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration
HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration
PRJNA542345 | ENA
ProteomicsSacsin, the ARSACS disease protein, controls lysosomal positioning and reformation by regulating microtubule dynamics
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a fatal brain disorder featuring cerebellar neurodegeneration leading to spasticity and ataxia. ARSACS is caused by mutations in the SACS gene that encodes sacsin, a massive 4579 amino acid protein with multiple modular domains. H...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD033823 | Pride
Lysosome Alr Microtubule 
GenomicsKATNAL2 Dysfunction Impairs Microtubule Dynamics and Contributes to Syndromic Neurodevelopmental Disease
KATNAL2 Dysfunction Impairs Microtubule Dynamics and Contributes to Syndromic Neurodevelopmental Disease
PRJNA1525560 | ENA
ProteomicsEffect of GP130 Antagonism on Microtubule Associated Proteins
TMT10plex analysis of microtubule associated proteins from right ventricular extracts of 3 control rats, 3 monocrotaline rats, and 4 monocrotaline rats treated with the GP130 antagonist SC144.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2021-07-19 | MSV000087852 | MassIVE
GenomicsCircZNF609 regulates microtubule dynamics ad tumorigenicity by sustaining CKAP5 protein levels.
CircZNF609 regulates microtubule dynamics ad tumorigenicity by sustaining CKAP5 protein levels.
PRJNA728673 | ENA
ProteomicsAurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.
Precise regulation of kinetochore-microtubules is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of Aurora B is the N-terminal “tail” domain of Hec1/NDC80, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-28 | PXD006892 | Pride
Human aurora a kinase hec1 
TranscriptomicsBreast cancer cell lines treated with eribulin and paclitaxel
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a mechanistically unique inhibitor of microtubule dynamics, leading to inhibition of microtubule growth in the absence of effects on microtubule shortening at microtubule plus ...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-50811 | biostudies-arrayexpress
ProteomicsPolarized microtubule remodeling transforms activated microglia morphology and drives cytokine release
Microglial activation is a pathological hallmark in many neurodegenerative diseases. During activation, microglia undergo complex morphological changes, including loss of their characteristic ramified cell morphology, which is routinely used to detect and quantify inflammation in the brain. However,...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090254 | MassIVE
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